Lentinula edodes (shiitake mushroom) is the medicinal macro-fungus popular in Japan and China. It second most well- known edible fungus global market after Agaricus bisporus Because of presence dietary fibers, vitamins, proteins, minerals carbohydrates, shiitake mushroom have significant nutritional worth. commonly cultivated winter season as “elixir life”. Bioactive compounds such polysacchari...

quinolines, an important class of potentially bioactive compounds, have been synthesized by treatment of o-aminoarylketones and carbonyl compounds utilizing niobium (v) chloride / polyethylenglycole(nbcl5.peg) and niobium(v)chloride (nbcl5) as available and inexpensive catalysts. the quinoline derivatives were prepared in glycerol, an excellent solvent in terms of environmental impact, with hig...

High antioxidant levels in food are gradually becoming popular because of enhanced risk oxidative stress humans. Bread wheat is rich vital antioxidants, but a major portion its bioactive compounds not available to This study was conducted with the aim fulfill antioxidants and nutrients gap between potential grains through fermentation by Bacillus subtilis KCTC 13241. In this experiment, whole w...

Baclofen (1) is a potent and selective agonist for bicuculline-insensitive GABA(B) receptors and is used clinically as an antispastic and muscle relaxant agent. In the search for new bioactive chemical entities that bind specifically to GABA(B) receptors, we report here the synthesis of certain baclofen homologues, namely (R,S)-5-amino-3-arylpentanoic acid hydrochlorides (R,S)-1a-h as well as (...

The detection of diverse chemical structures by the vertebrate olfactory system is accomplished by the recognition of odorous ligands by their cognate receptors. In the present study, we used computational screening to discover novel high-affinity agonists of an olfactory G protein-coupled receptor that recognizes amino acid ligands. Functional testing of the top candidates validated several ag...

Fruit including berries have been demonstrated to exhibit a broad spectrum of benefits including protection against cardiovascular, neurological, and lung diseases, as well as having antioxidant, antimicrobial, anti-inflammatory, antidiabetic and anti-aging properties. These protective effects are reported to be due to their high content of bioactive compounds, such as vitamin C, vitamin E, phe...

Hydroxypipecolic acids are bioactive compounds widely distributed in nature and are valuable building blocks for the organic synthesis of pharmaceuticals. We have found a novel hydroxylating enzyme with activity toward L-pipecolic acid (L-Pip) in a filamentous fungus, Fusarium oxysporum c8D. The enzyme L-Pip trans-4-hydroxylase (Pip4H) of F. oxysporum (FoPip4H) belongs to the Fe(II)/α-ketogluta...

The present work includes synthesis of new series heterocyclic derivatives containing 6-amino-1,3-dimethyl uracil moiety linked to 1,2,4-triazole [6-8 and 10]. first way reaction 6-amino-1,3-dimethyluracil with ethyl chloroacetate K2CO3 as catalyst in DMF solvent gives ester derivative [1]. Then, compound [1] was converted into (semicarbazide, thiosemicarbazide, phenylsemicarbazide hydrazide de...

Due to their potential biomedicinal and synthetic applications, b-amino acids have attracted a great deal of attention recently [1–6]. The derived b-peptides of several amino acids have been reported to exhibit certain secondary structures and special stability against peptidase [7,8]. For example, the b-oligopeptides of six b-amino acid residues form stable helices in methanol [8]. Furthermore...