some drugs have low bioavailability due to their poor aqueous solubility and/or slowdissolution rate in biological fluids. stiripentol (stp) is a novel anticonvulsant drug that isstructurally unrelated to the currently available antiepileptics. it has poor aqueous solubilityand its solubility has to be enhanced accordingly. polyethyleneglycol 6000 (peg-6000) iscommonly utilized as a hydrophilic...

We obtain in this paper topological models of binary differential equation at local codimension 2 singularities where all the coefficients of the equation vanish at the singular points. We also study the bifurcations of these singularities when the equation is deformed in a generic 2-parameter families of equations.

Extended Hildebrand solubility approach is used to estimate the solubility of nabumetone in binary solvent systems. The solubility of nabumetone in various propylene glycol-water mixtures was analyzed in terms of solute-solvent interactions using a modified version of Hildebrand-Scatchard treatment for regular solutions. The solubility of nabumetone in the binary solvent, propylene glycol-water...

The water solubility in fatty acid esters and biodiesels and the vapor–liquid equilibria (VLE) of fatty acid ester + methanol/ethanol systems, formed at biodiesel production and purification industrial units, were modeled in this work to complete the development and application of the soft-SAFT equation of state (EoS) to the design and optimization of biodiesel production plants. The soft-SAFT ...

Solubility of 2,6-diphenyl-4-(2,4,6-triphenylpyridinium-l-yl) phenolate, commonly known as Reichardt' s betaine dye and a ketocyanine dye has been determined in binary solvent mixtures and in cationic and anionic micellar media. In all the binary mixtures the standard molar free energy of solution, as given by log Sl2 where 512 is the solubility in the binary mixture, cannot be represented by t...

supercritical carbon dioxide has gained increasing attention in food and pharmaceutical processing owing to the fact that it is environmentally inexpensive, not flammable, essentially non-toxic, and it has a convenient critical point. also, it has been attracting much attention in many fields, such as extraction of sensitive materials and pharmaceutical processing and polymerization processes. ...