BACKGROUND AND PURPOSE Protein kinase C epsilon (epsilonPKC) has been implicated as a neuroprotectant in vitro. We studied epsilonPKC activation (by its localization and proteolysis) in a rodent stroke model and correlated the effects of hypothermia with epsilonPKC activity after cerebral ischemia. METHODS Rats were subjected to permanent distal middle cerebral artery occlusion plus 1 hour of...

Cerebral lactate, pyruvate and adenosine triphosphate (ATP), and acid-base balance were measured in male and female spontaneously hypertensive rats (SHR) before, and 1, 3 and 5 hours after bilateral carotid occlusion. In male SHR, cerebral lactate and the lactate/pyruvate (L/P) ratio progressively increased after occlusion, while cerebral ATP decreased. In female SHR, an increase in lactate and...

The role of the carotid sinus reflex in control of the blood flow in the left circumflex coronary artery was studied in nine open-chest dogs anesthetized with chloralose. Flow was measured with an electromagnetic flowmeter. The effects of bilateral common carotid occlusion were examined in a three-part experiment in each dog. (1) Under vagotomy (control) conditions, occlusion of both common car...

There is accumulating evidence, that ischemic preconditioning - a non-damaging ischemic challenge to the brain - confers a transient protection to a subsequent damaging ischemic insult. We have established bilateral common carotid artery occlusion as a preconditioning stimulus to induce early ischemic tolerance to transient focal cerebral ischemia in C57Bl6/J mice. In this video, we will demons...

A new model of bilateral hemispheric ischemia was created in the rat by occluding the common carotid arteries and the basilar artery; this resulted in consistent and severe impairment of the cerebral blood flow. The procedure for producing this model is described, and the results of EEG and autoradiography obtained by this model are compared to those obtained by the four-vessel occlusion model.

Carotid occlusion is a common disease and its incidence is about 6 in 100000. Annual risk of stroke is between 3% and 10% in older than 60 years with carotid occlusion and recurrent ischemic event have been reported in 25% of symptomatic carotid occlusion.1 Since many years ago it has been advocated in complete arterial occlusion, there was no chance for emboli to pass into the distal circulati...

vertebrobasilar insufficiency is the cause of cerebrovascular accidents in 20% of cases. there are few reports regarding spectral doppler indices (sdis) of vertebral arteries (vas) normal blood flow. the objective of this study was to provide basic reference data about sdis of vas normal blood flow separately and in comparison with internal carotid arteries (icas) and common carotid arteries (c...

The purpose of this study was to investigate whether the anatomic origin of micro-emboli influences their intracranial distribution. In twenty-two baboons, we examined the distribution of 99-Technetium labelled albumin aggregates (5 to 40 microns in size) after injection into the circulation at the left atrium (LA), carotid trifurcation (CA), and anterior and posterior common carotid artery (CC...