OBJECTIVES To compare the efficacies of medium-dose fluticasone propionate (FP), medium-dose triamcinolone acetonide (TAA), and combined low-dose FP plus salmeterol (SL). DESIGN Randomized, double-blind, triple-dummy, multicenter, 12-week clinical trial. SETTING Allergy/respiratory care clinics. PATIENTS Six hundred eighty patients with asthma previously uncontrolled with low-dose inhaled...

STUDY OBJECTIVES To investigate the potential for mometasone furoate (MF) to exert systemic effects following administration by dry powder inhaler (DPI) or metered-dose inhaler (MDI). DESIGN Three randomized, evaluator-blind, placebo-controlled, parallel-group, 28-day studies. PATIENTS Adults with mild-to-moderate persistent asthma. INTERVENTIONS Study 1 (12 patients per treatment group; ...

We analyze a dynamic informationally restricted auction mechanism a rental car company created to sell its cars. All bids are submitted via the internet in continuous time in ascending price auctions that last for two minutes. Unlike English or Japanese auctions, bidders do not observe the number of other bidders in the auction or their bids. At any time in the auction each bidder only knows a)...

Body image disturbance (BID) refers to persistent dissatisfaction, distress, and dysfunction related to some aspect(s) of one's physical appearance. Cognitive models of BID highlight the importance of dysfunctional beliefs in maintaining BID. Relational Frame Theory (RFT), in contrast, posits that psychological distress is sustained by the unwillingness to experience aversive internal experienc...

PURPOSE The primary objective of this study was to assess long-term safety with sublingual asenapine 2.5 or 5 mg twice daily (BID) in patients with schizophrenia. PATIENTS AND METHODS Actively treated patients on asenapine 2.5 mg BID, asenapine 5 mg BID, or olanzapine 15 mg once daily (QD) who completed a 6-week randomized, double-blind, placebo- and olanzapine-controlled study continued lead...

Bid-prices are becoming an increasingly popular method for controlling the sale of inventory in revenue management applications. In this form of control, threshold—or ‘‘bid’’—prices are set for the resources or units of inventory (seats on flight legs, hotel rooms on specific dates, etc.) and a product (a seat in a fare class on an itinerary or room for a sequence of dates) is sold only if the ...

BACKGROUND Atrial fibrillation (AF) requires arrhythmogenic changes in atrial ion channels/receptors and usually altered atrial structure. AF is commonly treated with antiarrhythmic drugs; the most effective block many ion channels/receptors. Modest efficacy, intolerance, and safety concerns limit current antiarrhythmic drugs. We hypothesized that combining agents with multiple anti-AF mechanis...