BACKGROUND Aortic valve stenosis (with or without aortic regurgitation and without associated mitral stenosis) in adults in the Western world has been considered in recent years to most commonly be the result of degenerative or atherosclerotic disease. METHODS AND RESULTS We examined operatively excised, stenotic aortic valves from 932 patients aged 26 to 91 years (mean+/-SD, 70+/-12), and no...

Aortic valve stenosis constitutes 3-6% of congenital heart diseases with an incidence of 1-4 per 10,000 live births (Khalid et al, 2006). The prevalence of aortic stenosis at birth is 0.03% (Mahle et al, 2010). If left untreated, it can lead to considerable morbidity and mortality in neonates, infants, children and adults. Until three decades ago, the only treatment that could be offered to chi...

Acute aortic dissection is typically seen in the middle aged and elderly population, the majority of the cases are related to systemic hypertension and atherogenic process. In contrast, aortic dissection-related deaths in the young are rare and are mainly associated with genetically based disorders and congenital cardiac anomalies. One of the most recognized congenital risk factors that predisp...

flow CMR in assessment of valve-related ascending aortic disease. JACC Cardiovasc Imaging 2011;4:781–7. 32. Barker AJ, Markl M, Burk J, Lorenz R, Bock J, Bauer S et al. Bicuspid aortic valve is associated with altered wall shear stress in the ascending aorta. Circ Cardiovasc Imaging 2012;5:457–66. 33. Schaefer BM, Lewin MB, Stout KK, Byers PH, Otto CM. Usefulness of bicuspid aortic valve phenot...

Congenital aortic valve anomalies are the cause of premature aortic stenosis in pediatric and younger adult populations. Despite being very rare, unicuspid aortic valves account for approximately 5% of isolated aortic valve replacements. Patients with aortic stenosis, present with the same symptomatology independent of leaflet morphology. However, the presence of bicuspid and unicuspid aortic s...

Athletes, firefighters and pilots are often in intense working stress. They are prone to have heart attack, especially in the condition of a bicuspid aortic valve. Aortic regurgitation and aortic wall weakness are often complicated with bicuspid aortic valve, thereby placing these professionals in a more dangerous circumstance. An appropriate screening strategy and further annual cardiovascular...

OBJECTIVE The optimal diameter at which replacement of the ascending aorta should be performed in patients with bicuspid aortic valve disease is not known. METHODS We reviewed all patients with bicuspid aortic valves undergoing aortic valve replacement at our institution from 1979 through 1993 (n = 201). Patients undergoing concomitant replacement of the ascending aorta were excluded. RESUL...

Citation: Forte A and Della Corte A (2017) Editorial: The Pathogenetic Mechanisms at the Basis of Aortopathy Associated with Bicuspid Aortic Valve: Insights from “Omics”, Models of Disease and Emergent Technologies. Front. Physiol. 8:1002. doi: 10.3389/fphys.2017.01002 Editorial: The Pathogenetic Mechanisms at the Basis of Aortopathy Associated with Bicuspid Aortic Valve: Insights from “Omics”,...

Unicuspid aortic valve was first described more than half a century ago (Edwards, 1958). Although reported infrequently, the natural history of unicuspid aortic valve is poorly understood. Developmental abnormalities of aortic valve cusps in decreasing order of frequency include bicuspid (0.9%-1.3%), unicuspid (0.02%), quadricuspid (0.008%0.043%), and pentacupsid aortic valves (Cemri, 2000). De...

We present an unusual case of an intracardiac Eustachian valve cyst observed concurrently with atresia of the coronary sinus ostium, a persistent left superior vena cava (LSVC) and a bicuspid aortic valve. There have been several echocardiographic reports of Eustachian valve cysts; however, there is no report of multidetector computed tomography (MDCT) findings related to a Eustachian valve cys...