نتایج جستجو برای: bet thermodynamic

تعداد نتایج: 50013  

2016
Sudan N. Loganathan Nan Tang Jonathan T. Fleming Yufang Ma Yan Guo Scott C. Borinstein Chin Chiang Jialiang Wang

Ewing sarcoma is driven by characteristic chromosomal translocations between the EWSR1 gene with genes encoding ETS family transcription factors (EWS-ETS), most commonly FLI1. However, direct pharmacological inhibition of transcription factors like EWS-FLI1 remains largely unsuccessful. Active gene transcription requires orchestrated actions of many epigenetic regulators, such as the bromodomai...

Akbartabar, Iman , Nasirizadeh, Navid , Tayebi, Habib-Allah , Yazdanshenas, Mohammad Esmail ,

Background and Purpose: This study aimed to investigate the adsorption of Acid Blue 62 (AB62) as an anionic dye from aqueous solution onto as SBA-15/Polyaniline (SBA-15/PAni) mesoporous nanocomposite a low-cost adsorbent and feasible. Materials and Methods: Fourier transform infra-red spectroscopy (FTIR), Filed Emission Scanning Electron Microscope (FESEM), Transmission Electron Microscope (TE...

2013
Anastasia Wyce Yan Degenhardt Yuchen Bai BaoChau Le Susan Korenchuk Ming-Chih Crouthamel Charles F. McHugh Robert Vessella Caretha L. Creasy Peter J. Tummino Olena Barbash

BET (bromodomain and extra-terminal) proteins regulate gene expression through their ability to bind to acetylated chromatin and subsequently activate RNA PolII-driven transcriptional elongation. Small molecule BET inhibitors prevent binding of BET proteins to acetylated histones and inhibit transcriptional activation of BET target genes. BET inhibitors attenuate cell growth and survival in sev...

Journal: :American Journal of Respiratory Cell and Molecular Biology 2019

Journal: :Journal of immunology 2007
Jennifer L Matsuda Thaddeus C George James Hagman Laurent Gapin

T-bet is a transcription factor of the T-box family that regulates the expression of numerous immune system-associated genes. T-bet directs the acquisition of the Th1-associated genetic program in differentiating CD4(+) lymphocytes. It also influences the development of NK and NKT cells through its regulation of the IL-2/IL-15Rbeta-chain (CD122) and the trafficking of these lymphocytes through ...

In this research, at first ordinary Aloe Vera micropowder (OAMP) and its impregnated form (IAMP) as the natural sorbents were prepared and then characterized by several techniques such as Fourier transform spectrophotometry (FT-IR), Scanning electron microscopy (SEM), Elemental analysis (EA), Brunauer–Emmett–Teller and Barrett-Joyner-Halenda (BET/BJH) essay and X-ray powder diffraction (XRD). T...

Journal: :Journal of immunology 2010
Alejandro V Villarino Eugenio Gallo Abul K Abbas

Given the association with autoimmune disease, there is great interest in defining cellular factors that limit overactive or misdirected Th17-type inflammation. Using in vivo and in vitro models, we investigated the molecular mechanisms for cytokine-mediated inhibition of Th17 responses, focusing on the role of STAT1 and T-bet in this process. These studies demonstrate that, during systemic inf...

Journal: :Journal of immunology 2004
Barbara Bohle Andreas Breitwieser Bettina Zwölfer Beatrice Jahn-Schmid Margit Sára Uwe B Sleytr Christof Ebner

Counterregulating the disease-eliciting Th2-like immune response of allergen-specific Th lymphocytes by fostering an allergen-specific Th1-like response is a promising concept for future immunotherapy of type I allergy. The use of recombinant allergens combined with more functional adjuvants has been proposed. In this respect, we present a novel approach. The gene sequence encoding the major bi...

Journal: :Immunity 2004
Amy E Lovett-Racke Anne E Rocchini Judy Choy Sara C Northrop Rehana Z Hussain Robert B Ratts Devanjan Sikder Michael K Racke

As a means of developing therapies that target the pathogenic T cells in multiple sclerosis (MS) without compromising the immune system or eliciting systemic side effects, we investigated the use of T-bet-specific antisense oligonucleotides and small interfering RNAs (siRNA) to silence T-bet expression in autoreactive encephalitogenic T cells and evaluated the biological consequences of this su...

2013
Richard A O'Connor Helen Cambrook Katja Huettner Stephen M Anderton

T cells that produce both IL-17 and IFN-γ, and co-express ROR-γt and T-bet, are often found at sites of autoimmune inflammation. However, it is unknown whether this co-expression of T-bet with ROR-γt is a prerequisite for immunopathology. We show here that T-bet is not required for the development of Th17-driven experimental autoimmune encephalomyelitis (EAE). The disease was not impaired in T-...

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