The systematic description of the complex photophysical behaviour of pyrene in surfactant solutions in combination with a quantitative model for the surfactant concentrations reproduces with high accuracy the steady-state and the time resolved fluorescence intensity of pyrene in surfactant solutions near the cmc, both in the monomer and in the excimer emission bands. We present concise model eq...

Pyrene and its derivatives find application as fluorescent probes for monitoring the oxygen concentrations in air and various fluids. Photophysical characteristics of some commercially available derivatives of pyrene in silicone polymer matrix were studied in order to find out whether they could be employed as a substitute for pyrene in the pressure sensitive paint (PSP). The derivatives under ...

The metabolism of [Wlbenzo(a)pyrene with isolated hepatocytes from 3-methylcholanthrene-treated rats was examined with the aid of high pressure liquid chromatography. Covalent binding of [SHlbenzo(a)pyrene metabolites to the intracellular DNA was investigated. The effects of (Ynaphthoflavone, salicylamide, trichloropropene oxide, and diethylmaleate, individually or combined, on the metabolism a...

Pyrene removal by polycation-montmorillonite (MMT) composites and granulated activated carbon (GAC) in the presence of humic acid (HA) was examined. Pyrene, HA, and sorbent interactions were characterized by FTIR, fluorescence and zeta measurements, adsorption, and column filtration experiments. Pyrene binding coefficients to the macromolecules were in the order of PVPcoS (poly-4-vinylpiridine-...

Cytochrome P-450-catalyzed epoxidation of (-)-(7R,8R)-d\hydroxy-7,8-dihydrobenzo(a)pyrene to (+H7fl,8S)-dihydroxy(9S,10fl)-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene is now well recognized as the primary pathway by which benzo(a)pyrene is converted to an ultimate carcinogen. The present metabolism studies of 6-fluorobenzo(a)pyrene indicate (a) that the 6-fluoro substituent does not dramatically bl...

A highly purified and reconstituted hepatic microsomal monooxygenase system, completely free of epoxide hydrase and consisting of cytochrome P-448 from 3-methylcholanthrene-treated rats, NADPH-cytochrome c reductase, phosphatidylcholine, and NADPH, metabolizes benzo (a)pyrene to products highly mutagenic in strains TA 98 and TA 1538 of Salmonella typhimurium. The formation of mutagenic metaboli...

The potential effect of asbestos fibers on mutagenicity of benzo(a)pyrene was investigated by using the Ames test. Asbestos fibers without a coating of benzo(a)pyrene or benzo(a)pyrene when not dissolved in DMSO lacked any mutagenic effect in the Salmonella/mammalian microsome mutagenicity test. However, when benzo(a)pyrene was adsorbed onto asbestos, significant numbers of mutated bacteria wer...

DNA-like fluorescent oligomers composed of alkynyl beta-D-ribofuranosides bearing pyrene, perylene, and anthracene as a fluorophore were synthesized by solid-phase DNA synthesis. The fluorescent oligomers possess the defined number and order of the fluorophores. In these oligomers, the adjacent fluorophores efficiently interact with each other by hydrophobic interactions in their electronic gro...

Benzo(a)pyrene 4,5-oxide was rapidly reduced to benzo(a)pyrene by rat liver microsomes in the presence of reduced nicotinamide adenine dinucleotide phosphate when incubated anaerobically. The activity of benzo(a)pyrene 4,5oxide reductase was increased about seven times by pretreat ment of rats with 3-methylcholanthrene. The addition of riboflavin to the incubation mixture resulted in the increa...

A series of pyrene-based polycyclic aromatic compounds, indeno[cd]pyrene, diindeno[cd,fg]pyrene, diindeno[cd,jk]pyrene, tris-(tert-butylindeno[cd,fg,jk])pyrene, and tetrakis-(tert-butylindeno[cd,fg,jk,mn])pyrene, were reduced with alkali metals in [D8]tetrahydrofuran, and the resulting anions were studied by NMR spectroscopy. It was found that the diatropic character of the dianions obtained de...