Smart design and efficient synthesis of benzimidazole Ru, Ir and Rh cyclometalated complexes are reported with promising cytotoxic activity against HT29, T47D, A2780 and A2780cisR cancer cell lines. Their apoptosis, accumulation, cell cycle arrest, protein binding and DNA binding effects are also discussed.

In this communication, we report the synthesis, characterization, and electrochemistry of a 2-(2-hydroxyphenyl)-1H-benzimidazole-manganese oxide hybrid. Our results suggest that this compound is a promising model for the manganese cluster together with tyrosine-161 and histidine-190 in photosystem II of plants, algae and cyanobacteria.

A concise synthesis of benzimidazole-substituted β-amido-amide LLW62 is presented. The original synthesis of compounds related to LLW62 was developed on Rink resin as part of a "one-bead, one-compound" combinatorial approach for on-bead screening purposes. The current synthesis is carried out in solution and is amenable to scale-up for follow-up studies on LLW62 and investigations of related st...