[%]Penicillin G bound to the Bacillus subtilis and Bacillus stearothermophilus D-ala&e carboxypeptidases in either the membrane-bound or purified states. ‘Ihis binding was subsequently reversed with a half-time ranging from 10 min to several days, depending on the enzyme, the penicillin derivative, and the temperature. The released material was neither intact penicillin nor penicilloic acid but...

The purpose of this study was to compare the management of patients with a history of penicillin allergy between allergists and non-allergists in Thailand. A questionnaire was distributed to Thai physicians by online survey. The answers from 205 physicians were analyzed. The discrepancy of penicillin allergy management between allergists and non-allergists was clearly demonstrated in patients w...

Nosocomial infections are proving to be a menace for the whole health care system, with methicillin resistant Staphylococcus aureus (MRSA) being very notorious causative agent. Along role of mecA gene producing penicillin-binding protein (PBP2a), production beta-lactamase enzyme by makes organism all β-lactam agents. This study aims at phenotypic detection resistance and β-Lactamase in S. isola...

The mechanism of penicillin immediate hypersensitivity reactions has not been completely elucidated. These reactions are generally considered to be mediated by IgE, but penicillin-specific IgE could not be detected in most cases. This study demonstrated that penicillin was able to cause vascular hyperpermeability in a mouse model mimicking clinical symptoms of penicillin immediate hypersensitiv...

a synergic interaction. Evidence was obtained that gentamicin interfered with bacterial lysis induced by penicillin, and this suggests that the aminoglycoside is responsible for the bactericidal activity of the combination, the role of the penicillin being solely to facilitate access of the aminoglycoside to its target site. Our findings do not, however, fully support the generally held view th...