Background: Three most frequent primary skin cancers are basal cell carcinoma (BCC), squamous (SCC) and malignant melanoma. Together SCC BCC referred to as non-melanoma (NMSC). NMSCs comprise of 1-2% all diagnosed in India contrast one-third whites. represents 30%-65% blacks Indians, whereas contributes 65%-75% whites.
 Methods: Total 100 cases Non-melanocytic Tumors were studied retrospec...

OBJECTIVES Melanomas of the female genital tract present a unique clinical challenge. Not only are these lesions in an anatomically sensitive area, but also they tend to be multifocal and have high recurrence rates. Furthermore, several benign melanocytic proliferations resemble early-stage melanoma clinically and/or histopathologically. Thus, there is a significant need for additional tools th...

In 2-8% of patients with melanoma, the first clinical manifestation of the disease may be skin metastasis. In these cases, differential diagnosis with the primary melanoma, benign melanocytic lesions, and other malignant and benign skin growths is particularly challenging. For this reason, the dermatologist's approach to cutaneous metastases of malignant melanoma calls for knowledge of the grea...

BACKGROUND Although nucleic acid derangements are the hallmark of melanocytic dysplasia, the gold standard for its diagnosis remains the microscopic evaluation of haematoxylin and eosin stained slides. However, light microscopy is subjective and crucial genomic changes do not always show as changes in histology. AIMS To introduce the nucleic acid index (NAI) as a means of analysing nucleic ac...

BACKGROUND Melanoma is the major cause of skin cancer death worldwide. Parkinson's disease is a neurodegenerative disorder that is caused by mutation of alpha-synuclein or other genes. Importantly, epidemiological studies have reported co-occurrence of melanoma and Parkinson's disease, suggesting that these two diseases could share common genetic components. METHODOLOGY/PRINCIPAL FINDINGS Rec...

There are some important indications in mini lesions (MLs), such as benign melanocytic lesions and superficial nevi. Shave excision, which is performed to treat these kind of lesions (figure 1), is frequently applied; but, the possibility of recurrence and the actual cosmetic results achieved with this procedure (shave excision) remains a controversial issue (Ferrandız, 2005; Bong et al., 2003;...

BACKGROUND Melanocytic proliferations are common in horses but the diagnosis of malignancy is not always straightforward. To improve diagnosis and prognosis, markers of malignancy are needed. Receptor for activated C kinase 1 (RACK1) protein may be such a marker. RACK1 was originally found to characterize malignant melanocytic lesions in the Melanoblastoma-bearing Libechov minipig (MeLiM) and, ...

BACKGROUND The dermoscopic features of vulvar melanosis lesions are well known. To our knowledge, there are only a few case reports about dermoscopic features of pigmented genital lesions in male patients. OBJECTIVE To evaluate dermoscopic and clinical characteristics of benign lesions of the genital area in both males and females, and to assess the distinguishing dermoscopic criteria of vulv...