A major obstacle to the development of effective treatment of Alzheimer's disease (AD) is successfully delivery of drugs to the brain. We have previously identified a series of benzothiazole phosphonate compounds that block the interaction of amyloid-β peptide with amyloid-β binding alcohol dehydrogenase (ABAD). A selective and sensitive method for the presence of three new benzothiazole ABAD i...

Current strategies for the treatment of Alzheimer's disease (AD) involve tackling the formation or clearance of the amyloid-beta peptide (Aβ) and/or hyper-phosphorylated tau, or the support and stabilization of the remaining neuronal networks. However, as we gain a clearer idea of the large number of molecular mechanisms at work in this disease, it is becoming clearer that the treatment of AD s...

A usability study evaluating dynamic tunnel concepts has been completed under the Aviation Safety and Security Program, Synthetic Vision Systems Project. The usability study was conducted in the Visual Imaging Simulator for Transport Aircraft Systems (VISTAS) III simulator in the form of questionnaires and pilot-in-the-loop simulation sessions. Twelve commercial pilots participated in the study...

The application of mine method shallow burying and undercutting in subway tunnel engineering is becoming more significant, but also has its own limitations: the can easily cause subsidence nearby surface, there a security threat to surrounding buildings, instability inside, easy collapse construction tunnels, endangering safety, so ensuring safety becomes key project. By combining examples Heyi...

The planned new Heavy Ion Synchrotron SIS 100/300 for the FAIR Project will consist of two separate tunnels. In addition to the tunnel where the beam lines itself will be situated, there will be an additional tunnel, for maintenance and supply purposes. This maintenance tunnel is desired to be accessible for technical personnel also during beam operation. Therefore, from the radiation safety po...

Based on the comprehensive analyses of many risk factors leading to accidents in immersed tunnel engineering, it is concluded that engineering are very large and must be paid attention all aspects at stages project. This paper classifies identifies by investigating visiting relevant investigation, design construction units tunnel, then puts forward prevention control measures provide theoretica...

In a Perspective accompanying Abad-Franch and colleagues, Lorenz von Seidlein, Alexander Kekulé, and Daniel Strickman discuss the importance of developing effective strategies to minimize mosquito-borne transmission of human diseases.

BACKGROUND Since Pars Abad district had been known as a focus of visceral leishmaniasis (VL) in Ardabil Province but the prevalence of the disease in nomadic tribes has not been determined, thus, this study was conducted. METHODS This descriptive cross-sectional study was conducted on children up to 12yr old of nomadic tribes from Pars Abad County, Ardabil Province, Iran in 2015. For each ind...

In the acute setting, the majority of patients affected by uncomplicated acute type B aortic dissection (ABAD) can be managed with medical therapy. In these patients, inhospital outcome is generally acceptable, with mortality rates of 1-10% (1,2). However, long-term outcomes in this group is less positive, with a mortality rates reported as 2025% within 3 years. Predictors of long-term complica...