materials and methods an oligogearray® (an oligonucleotide-based gene expression array platform) containing 126 wnt signaling pathway-related genes was used to compare gene expressions between primary hcc and adjacent non-tumorous liver tissues from 10 patients with hcc. selected differential genes were identified with real-time rt-pcr and immunohistochemistry (ihc). in particular, the protein ...

In many species, under varying ecological conditions, social interactions among individuals result in the formation of dominance hierarchies. Despite general similarities, there are robust differences among dominance hierarchies across species, populations, environments, life stages, sexes, and individuals. Understanding the proximate mechanisms underlying the variation is an important step tow...

Coordinated mRNA translation at the synapse is increasingly recognized as a critical mechanism for neuronal regulation. Pumilio, a translational regulator, is known to be involved in neuronal homeostasis and memory formation in Drosophila. Most recently, the mammalian Pumilio homolog Pumilio-2 (Pum2) has been found to play a role in the mammalian nervous system, in particular in regulating morp...

Computer forensics is the application of investigation and analysis techniques to gather and preserve evidence from a particular computing device in a way that is suitable for presentation in a court of law. Behavior analysis is rooted in the behaviorist tradition and utilizes learning principles to bring about behavior change. Digital forensics is a branch of forensic science encompassing the ...

A major hindrance for the development of psychiatric drugs is the prediction of how treatments can alter complex behaviors in assays which have good throughput and physiological complexity. Here we report the development of a medium-throughput screen for drugs which alter anxiety-like behavior in adult zebrafish. The observed phenotypes were clustered according to shared behavioral effects. Thi...

The criminal profiling technique, developed in the second half of last century, has proved to be a useful resource as an investigative especially when conventional techniques have not been productive and is closely associated with Behavioral Sciences Forensic Criminology, being used direct investigate by reducing number suspects crime. Among various methodologies available, Crime Scene Analysis...

Content moderation is an essential part of online community health and governance. While much extant research centered on what happens to the content, also involves management violators. This study focuses how moderators (mods) make decisions about their actions after violation takes place but before sanction by examining they "profile" Through observations interviews with volunteer mods Twitch...