Severe allergic reactions during specific immunotherapy may occur in the treatment of hymenoptera sting allergy. The objective of the present study was to examine the characteristics of allergic reactions during specific immunotherapy in patients with allergy towards hymenoptera venom in the Iranian population. A prospective study was performed using the clinical reports of 27 patients with ana...

Current guidelines for venom immunotherapy suggest that immunotherapy should be performed only in patients with IgE mediated systemic reactions. However, opinions on the diagnosis and treatment of patients with systemic reactions in the absence of IgE are quite varied. We present a patient with a history of atypical systemic reactions after a bee sting. Skin tests and specific IgE for bee venom...

Summary A cross-cultural translation of the Vespid Allergy Quality of Life Questionnaire (VQLQ) to the Portuguese population (VQLQ-P) was performed, assessing its applicability in wasp and in non-beekeeper bee venom allergic patients. Additionally, we evaluated a Visual Analogue Scale (VAS) to estimate hymenoptera allergy interference with daily life. Methods. Cross-cultural translation was per...

Introduction: Idiopathic premature ovarian failure is defined as cessation of menstruation before the expected age of menopause (40 years) without detectable cause. the definitive line of treatment is egg donation which is not accepted in many countries. Bee venom is a miracle it has a unique composition so the aim of this work is to use ultrasound guided intra ovarian injection of Bee venom as...

BACKGROUND AND OBJECTIVE Different clinical behaviors have been identified in patients allergic to bee venom. Compound-resolved diagnosis could be an appropriate tool for investigating these differences. The aims of this study were to analyze whether specific IgE to Api m 4 (sIgE-Api m 4) can identify a particular kind of bee venom allergy and to describe response to bee venom immunotherapy (bV...

AIM To evaluate markers of mast cell and basophil activation in children undergoing the initial phase of honeybee venom immunotherapy (VIT). PATIENTS & METHODS Five children (four boys and one girl) aged 9.5-18 years with severe systemic bee sting reactions and confirmed IgE-mediated allergy were enrolled. Plasma and urine concentrations of 9α,11β-PGF2 and serum tryptase levels were measured ...

High dose bee venom exposure in beekeepers by natural bee stings represents a model to understand mechanisms of T cell tolerance to allergens in healthy individuals. Continuous exposure of nonallergic beekeepers to high doses of bee venom antigens induces diminished T cell-related cutaneous late-phase swelling to bee stings in parallel with suppressed allergen-specific T cell proliferation and ...

Bee venom (BV) was used from long time ago in the medical field as treatment of chronic joint affections. In the recent decades, the screening process of new sources of antimicrobials discovers its high advantageous characteristics for combating various types of microbes, as well as trials to discover its anti-cancer medicinal fields. Lumpy skin disease virus (LSDV) causes disease in cattle of ...

BACKGROUND Diluted bee venom (BV) is known to have anti-nociceptive and anti-inflammatory effects. We therefore assessed whether perineural bee venom pretreatment could attenuate the development of neuropathic pain in the spinal nerve ligation injured animal model. METHODS Neuropathic pain was surgically induced in 30 male Sprague Dawley rats by ligation of the L5 and L6 spinal nerves, with 1...

Multiple sclerosis (MS) is a progressive, neurodegenerative disease of central nervous system (CNS). Experimental allergic encephalomyelitis (EAE) is a widely accepted animal model for MS. Honey bee venom (Apis mellifera) contains a variety of low and high molecular weight peptides and proteins including melittin, apamin, adolapin, mast cell degranulating peptide and phospholipase A2. Bee venom...