The ‘social relations of science’ movement grew to prominence in the 1930s. Its story has been told by McGucken (1984), MacLeod and MacLeod (1976), and Werskey (1978) among others. The movement consisted of predominantly left-wing scientists who held that science could and should be applied to the alleviation of social problems, and that a rationally planned society was more just, and more effi...

Epidemiologic studies demonstrate that obesity is associated with an aggressive subtype of breast cancer called basal-like breast cancer (BBC). Using the C3(1)-TAg murine model of BBC, we previously demonstrated that mice displayed an early onset of tumors when fed obesogenic diets in the adult window of susceptibility. Obesity was also shown to elevate mammary gland expression and activation o...

An improved density matrix functional [correction to Buijse and Baerends functional (BBC)] is proposed, in which a hierarchy of physically motivated repulsive corrections is employed to the strongly overbinding functional of Buijse and Baerends (BB). The first correction C1 restores the repulsive exchange-correlation (xc) interaction between electrons in weakly occupied natural orbitals (NOs) a...

We consider the efficient implementation of matrix computations in interpreted Basic on a microcomputer. Linear equations routines SGEFA and SGESL from the LINPACK library of Fortran programs are translated into Basic and run on four microcomputers: the Commodore 64, the Amstrad CPC 464, the BBC Microcomputer, and the BBC with a Z-80 second processor. The computational cost of the routines is f...

Previous experimental studies to assess the contribution of blood-borne circulating (BBC) cells to cutaneous wound healing have relied on discontinuous pulsing of labeled BBC elements or bone marrow transplant protocols. Such approaches do not allow the examination of stable BBC cells that have matured in a physiologically normal host. We have used a parabiotic murine model for cutaneous wound ...

Basal-like breast cancers (BBCs) are enriched for increased EGFR expression and decreased expression of PTEN. We found that treatment with metformin and erlotinib synergistically induced apoptosis in a subset of BBC cell lines. The drug combination led to enhanced reduction of EGFR, AKT, S6 and 4EBP1 phosphorylation, as well as prevented colony formation and inhibited mammosphere outgrowth. Our...

In the mid 90s, a colleague had a brand new Palm III, we were waiting on a train station in a small Dutch city and began dreaming: what if we could use this Palm to get information about this location, about interesting places around the station and so on and so forth. Back at home we wrote a project proposal and we received funding for the MIA Project [4]. This was the beginning of a series of...

In Bangladesh, the BBC Janala project is using multimedia to give adults opportunities to learn English for economic purposes. English lessons are available on mobile phones, the web, a newspaper and a TV show. Despite the large numbers of people accessing the BBC Janala media products, there is a gendered digital divide, with much fewer women accessing the web and mobile lessons in particular....

The ‘social relations of science’ movement grew to prominence in the 1930s. Its story has been told by McGucken (1984), MacLeod and MacLeod (1976), and Werskey (1978) among others. The movement consisted of predominantly left-wing scientists who held that science could and should be applied to the alleviation of social problems, and that a rationally planned society was more just, and more effi...