A longitudinal study refers to collection of a response variable and possibly some explanatory variables at multiple follow-up times. In many clinical studies with longitudinal measurements, the response variable, for each patient is collected as long as an event of interest, which considered as clinical end point, occurs. Joint modeling of continuous longitudinal measurements and survival time...

the objective of this study was to compare six statistical methods for prediction of genomic breedingvalues for traits with different genetic architecture in term of gene effects distributions and number ofquantitative traits loci (qtls). a genome consisted of 500 bi-allelic single nucleotide polymorphism(snp) markers distributed over a chromosomes with 100 cm length was simulated. three differ...

objectives : schizophrenia patients often experience relapses once and even more with no limit on number of relapses. the time among relapses are rarely considered in studies. the aim of this study was to identify some risk factors of time to elapses in schizophrenic patients with recurrent events model in survival analysis. methods : in a retrospective longitudinal study, the medical records o...

the  main  assumptions  in  liner  mixed  model  are normality  and  independency  of  random  effect component.   unfortunately,   these   two  assumptions   might   be  unrealistic   in  some   situations. therefore, in this paper, we will discuss about the analysis of bayesian analysis of non-normal and non-independent mixed model using skew-normal/independent distributions, and finally, thi...

a new structure learning approach for bayesian networks (bns) based on asexual reproduction optimization (aro) is proposed in this letter. aro can be essentially considered as an evolutionary based algorithm that mathematically models the budding mechanism of asexual reproduction. in aro, a parent produces a bud through a reproduction operator; thereafter the parent and its bud compete to survi...