The impact of carbapenemase production among clinically significant Gram-negative rods is becoming a major medical issue. To date, Acinetobacter baumannii has been considered as a final recipient of carbapenemase genes (imipenemase, Verona metallo-β-lactamase, Guiana extended-spectrum β-lactamase and Klebsiella pneumonia carbapenemase types) from Enterobacteriaceae and Pseudomonas aeruginosa. H...

Acinetobacter species are aerobic gram-negative organism being responsible for various types of infections such as pneumonia, urinary tract infection and septicemia [1-4]. The Acenitobacter infections have been recognized as an emerging problem and appeared to be associated with high mortality rates throughout the world. Very recently, it has been reported that Acinetobacter species accounts fo...

Acinetobacter baumannii plays an increasing role in the pathogenesis of infections in humans. The bacilli are frequently isolated from patients treated in intensive care units. A growing resistance to antibiotics is leading to the emergence of strains that are multidrug-resistant and resistant to all available agents. The objective of this study was to assess susceptibility to antibiotics and t...

abstract please cite this article as: goudarzi h, douraghi m, ghalavand z, goudarzi m. assessment of antibiotic resistance pattern in acinetobacter baumannii carrying bla oxa type genes isolated from hospitalized patients. novel biomed 2013;1(2):54-61. introduction: acinetobacter baumannii is a gram-negative coccobacillus and one of the most opportunistic pathogens responsible for serious infec...

Polymyxins are often last-line therapeutic agents used to treat infections caused by multidrug-resistant A. baumannii. Recent reports of polymyxin-resistant A. baumannii highlight the urgent need for research into mechanisms of polymyxin resistance. This study employed genomic and transcriptomic analyses to investigate the mechanisms of polymyxin resistance in A. baumannii AB307-0294 using an i...

Acinetobacter baumannii, a Gram-negative multidrug-resistant (MDR) bacterium, is now recognized as one of the more common nosocomial pathogens. Because most clinical isolates are found to be multidrug resistant, alternative therapies need to be developed to control this pathogen. We constructed a bacteriophage genomic library based on prophages induced from 13 A. baumannii strains and screened ...

BACKGROUND & OBJECTIVES Antibiotic resistant bacterial nosocomial infections are a leading problem in intensive care units (ICU). Present investigation was undertaken to know antibiotic resistance in Acinetobacter baumannii and some other pathogens obtained from clinical samples from ICU causing nosocomial infections. Special emphasis was given on plasmid mediated transferable antibiotic resist...

Nonmammalian model systems of infection such as Galleria mellonella (caterpillars of the greater wax moth) have significant logistical and ethical advantages over mammalian models. In this study, we utilize G. mellonella caterpillars to study host-pathogen interactions with the gram-negative organism Acinetobacter baumannii and determine the utility of this infection model to study antibacteria...

background: acinetobacter spp., as important opportunistic pathogens, have been found to be responsible for an increas­ing number of nosocomial infections. this study was undertaken to investigate the antimicrobial susceptibility and molecular typing of iranian isolates of a. baumannii . methods: the study was conducted over a period of 19 months in three hospitals in tehran, iran. acinetobacte...