Liposomal carriers, eminent for their potential in topical drug delivery have been chosen to help embedding of nystatin molecules in the skin layers. The objective of present study was to develop and carry out rheological investigations of nystatin liposomal gel by using optimization technology in terms of 2 factorial design. In this study attempts have been made to formulate liposomal dispersi...

Tenax-TA, a solid-phase sorbent, was used as an alternative to hexadecane for continuous delivery of tetrachloroethene (PCE) to Desulfuromonas strain BB1, a chloro-respiring microorganism. In both batch and bioreactor configurations, Tenax not only maintained low, steady-state concentrations of PCE in an active culture for several months but also adsorbed the product of dechlorination, cis-1,2-...

The delivery and courier services are entering a period of rapid change due to the recent technological advancements, E-commerce competition and crowdsourcing business models. These revolutions impose new challenges to the well studied vehicle routing problem by demanding a) more ad-hoc and near real time computation as opposed to nightly batch jobs of delivery routes for large number of delive...

A footwear business is one of highly competitive markets. Footwear businesses must continuously improve three main key performance measures namely quality, cost and lead time. The case study is one of footwear businesses in Thailand. As customer demands are fragmented, the company needs to offer different products to serve customers’ satisfaction. Customer orders are then small quantities, but ...

A commitment of delivery time is critical in some online businesses (De Koster, 2003). An important challenge to meeting customers’ needs is timely order picking which is also relevant to worker safety, item freshness, overall operational synchronization, and reduced overtime. We analyze an order batch picking situation where a trip is constrained by vehicle capacity and must be completed withi...

The therapeutic efficacy of antibodies can be successfully improved through targeted delivery of potent cytotoxic drugs in the form of antibody-drug conjugates. However, conventional conjugation strategies lead to heterogeneous conjugates with undefined stoichiometry and sites, even with considerable batch-to-batch variability. In this study, we have developed a chemo-enzymatic strategy by equi...

This paper considers an integrated routing and scheduling problem where the part takes into account costs tardiness penalties is modelled by a permutation flow shop with inventory costs. We assume that each batch served dedicated vehicle, number of batches their compositions (the jobs parameters those jobs) are known in advance. The to determine starting times on machine shop, departure dates d...

batch sizing in different planning period is categorized as a classical problem in production planning, that so many exact & heuristic methods have been proposed to solve this problem, each of which considering various aspects of the original problem. the solution obtained from majority – e.g. mrp – is in this format that there may be some periods of idleness or each period should produ...