Abstract Objective To investigate the regulation of T follicular regulatory (Tfr) and (Tfh) cell subtypes by low-dose IL-2 in systemic lupus erythematosus (SLE) a randomized, double-blind, placebo-controlled clinical trial. Methods A post hoc analysis was performed randomized cohort SLE patients (n=60) receiving therapy (n=30) or placebo (n=30), along with standard care treatment. The primary e...

INTRODUCTION Over the last few decades, total fertility rate (TFR) has followed a downward trend in Iran. The consequences of this trend from the perspectives of some are negative. Considering the macro-population policies in recent years, this study aimed to examine the effect of some macro socio-economic variables, including divorce, marriage, urbanization, and unemployment rate on TFR in Ira...

A new approach has been proposed to reduce the computations involved in the ISAR imaging, which uses Harmonic Wavelet (HW) based Time-Frequency Representation (TFR). Since the HW based TFR falls into a category of non-parametric Time-Frequency (T-F) analysis tool, it is computationally efficient compared to parametric T-F analysis tools such as Adaptive Joint Time-Frequency Transform (AJTFT), A...

BACKGROUND The serum transferrin receptor (TfR) concentration in adults is suggested to provide a sensitive measure of iron depletion and together with the serum ferritin concentration to indicate the entire range of iron status, from iron deficiency to iron overload. However, little is known about TfR concentrations in children. OBJECTIVE Our objective was to compare serum TfR and ferritin c...

An accurate time-frequency representation (TFR) can provide useful information in non stationary data analysis and processing. The traditional methods like short-time Fourier transform (STFT) and wavelet transform (WT) based TFR approaches are leads to a tradeoff between time and frequency resolution. A recently proposed synchrosqueezing transform (SST), which is an extension of the WT, has bee...

The transferrin receptor (TfR) interacts with two proteins important for iron metabolism, transferrin (Tf) and HFE, the protein mutated in hereditary hemochromatosis. A second receptor for Tf, TfR2, was recently identified and found to be functional for iron uptake in transfected cells (Kawabata, H., Germain, R. S., Vuong, P. T., Nakamaki, T., Said, J. W., and Koeffler, H. P. (2000) J. Biol. Ch...

BEFORE EXPLAINING why we disagree with the views expressed in the two preceding comments, we summarize briefly the purpose and main features of the method described in Bongaarts and Feeney (1998). Our study set out to address a well-known flaw in the total fertility rate, the most widely used measure of period fertility. The TFR is affected by changes in the timing of childbearing. In years whe...

Immunization leads to the formation of germinal centres (GCs) that contain both T follicular helper (Tfh) and T follicular regulatory (Tfr) cells. Whether T-cell receptor (TCR) specificity defines the differential functions of Tfh and Tfr cells is unclear. Here we show that antigen-specific T cells after immunization are preferentially recruited to the GC to become Tfh cells, but not Tfr cells....

The major route of iron uptake by cells occurs through transferrin receptor (TfR)-mediated endocytosis of diferric-charged plasma transferrin (holo-Tf). In this work, we pursued TfR antibodies as potential cancer therapeutics, characterizing human single-chain variable antibody fragments (scFv) specific for the human TfR isolated from a phage display library. We hypothesized that many of these ...