Loss of nucleoside diphosphate kinase (Ndk) function in Escherichia coli results in an increased frequency of spontaneous mutation and an imbalance in dNTP pool levels. It is presumed that the imbalance in dNTP pool levels is responsible for the mutator phenotype of an E. coli ndk mutant. A human homologue of Ndk and potential suppressor of tumor metastasis, nm23-H2, can complement the mutageni...

In everyday life, humans and animals often have to base decisions on infrequent relevant stimuli with respect to frequent irrelevant ones. When research in neuroscience mimics this situation, the effect of this imbalance in stimulus classes on performance evaluation has to be considered. This is most obvious for the often used overall accuracy, because the proportion of correct responses is gov...

Data imbalance is frequently encountered in biomedical applications. Resampling techniques can be used in binary classification to tackle this issue. However such solutions are not desired when the number of samples in the small class is limited. Moreover the use of inadequate performance metrics, such as accuracy, lead to poor generalization results because the classifiers tend to predict the ...

The concentration of ribonucleoside triphosphates (rNTPs) in cells is far greater than the concentration of deoxyribonucleoside triphosphates (dNTPs), and this pool imbalance presents a challenge for DNA polymerases (Pols) to select their proper substrate. This report examines the effect of nucleotide pool imbalance on the rate and fidelity of the Escherichia coli replisome. We find that rNTPs ...

The aim of computational learning algorithm is to establish grounds that work for any types of data, once and for all. However, majority of the classifiers have their base from balanced datasets. This paper discusses the issues related to imbalanced data distribution problem and the common strategy to deal with imbalance datasets. We propose a model capable of handling imbalance datasets well i...

"Wide-based gait" is considered indicative of imbalance. No quantitative gait analyses, however, have related base of support to steadiness during gait. To determine whether patients with cerebellar or vestibular disorders had a wider base of support than matched healthy individuals, we analyzed 102 balance-impaired patients and healthy subjects during free and paced gait. Kinematic data were c...

BACKGROUND The effectiveness of sodium bicarbonate (SB) has recently been questioned although it is often used to correct metabolic acidosis of neonates. The aim of the present study was to examine its effect on hemodynamic changes and hydrogen peroxide (H(2)O(2)) generation in the resuscitation of hypoxic newborn animals with severe acidosis. METHODS Newborn piglets were block-randomized int...

OBJECTIVE The present study was undertaken to study the frequency of electrolyte imbalance in children with diarrhoea and the relationship between electrolyte abnormalities and mortality. MATERIALS AND METHODS This is a retrospective, observational hospital based study. Fifty seven children admitted to paediatric ward with diarrhoea and dehydration was evaluated for electrolyte and acid base ...

Built-in self-test (BiST) for transmitters is a desirable choice since it eliminates the reliance on expensive instrumentation to perform radio-frequency signal analysis. Existing on-chip resources, such as power or envelope detectors or small additional circuitry, can be used for BiST purposes. However, due to limited bandwidth, measurement of complex specifications, such as in-phase and quadr...