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We compare two commonly used diagnostic approaches, one relying on plasma bicarbonate concentration and "anion gap," the other on "base excess," with a third method based on physicochemical principles, for their value in detecting complex metabolic acid-base disturbances. We analyzed arterial blood samples from 152 patients and nine normal subjects for pH, PCO(2), and concentrations of plasma e...

Objective: To determine how well neonatal blood base excess and lactate predict outcome following perinatal asphyxia. Study Design: Over 68 months, with around 9000 deliveries, lactate was measured on all blood gases taken from neonatal admissions, as well as mineral base and organic acid whenever electrolytes were required. Infants were classified according to their outcome more than 10 years ...

OBJECTIVE To assess the effect of epidural versus systemic labour analgesia on funic acid-base status at birth. DESIGN A systematic review of trials, both randomised and non-randomised, comparing epidural with systemic opioid analgesia. POPULATION Babies of 2102 mothers taking part in trials comparing epidural with systemic analgesia in five countries. METHODS From the published and unpub...

BACKGROUND The influence of common disturbances seen in preeclampsia, such as changes in strong ions and weak acids (particularly albumin) on acid-base status, has not been fully elucidated. The aims of this study were to provide a comprehensive acid-base analysis in severe preeclampsia and to identify potential new biological predictors of disease severity. METHODS Fifty women with severe pr...

Experimental excess wide-angle X-ray scattering curves from DNA in solution, from Na-DNA crystallites in mother-liquor, from mononucleosomes in solution and from nucleosome core histone complexes are compared with each other and with calculated excess scattering curves of DNA with variable number of base-pairs per turn. The DNA in the Na-DNA crystallites and in the mononucleosomes has on averag...

HYPOTHESIS Central venous blood gas (VBG) measurements of pH, PCO2, and base excess can be substituted for the same values obtained from an arterial blood gas (ABG) analysis in mechanically ventilated trauma patients, obviating the need for arterial puncture. DESIGN AND SETTING Prospective comparison of 99 sets of VBGs and ABGs at a level 1 academic trauma center. PATIENTS A consecutive sam...

BACKGROUND Propofol infusion syndrome is first manifest by unexplained metabolic acidosis. Its incidence is unknown. METHODS Charts of all patients undergoing nonsurgical, catheter radiofrequency ablation for atrial flutter or fibrillation from 1999 through 2001 at Mayo Clinic Rochester, who received propofol and had an arterial blood gas drawn during the procedure, were reviewed retrospectiv...