objective: experiments were conducted to find the differences between post-thaw viability and chromosome aberrations in eight-cell mouse embryos at presence of dimethyl sulfoxide (dmso) and 1, 2-propanediol (proh) as croprotectants in different storage durations. materials and methods: in this case-control study, a total number of 720 mouse embryos from about 250 nmri mice were vitrified with 3...

ABSTRACT We examined whether peripheral leukocytes of mice derived from in vitro αMEM-cultured embryos and exhibiting type 2 diabetes had higher expression inflammatory-related genes associated with the development atherosclerosis. Also, we impact a barley diet on inflammatory gene expression. Adult were produced by embryo transfer, after culturing two-cell for 48 h either α minimal essential m...

Objective(s) Quinazolinones are heterocyclic components (able to form cyclized compounds) which have several medical effects such as anti-malarial, spasmolytic, anti-microbial, sedative, etc. They are also known for their fungicidal properties, inhibition of tyrosine-kinase and DNA repair enzyme poly (ADP-ribose) polymerase (PARP) and are also effective in treatment of cancer, diabetes, and pa...

background: timing of the first zygotic cleavage is an accurate predictor of embryo quality. embryos that cleaved early (ec) have been shown to exhibit higher developmental viability compared to those that cleaved at a later period (lc). however, the viability of ec embryos in comparison to lc embryos after vitrification is unknown. the present study aims to investigate the post-vitrification d...

Background: For several years, mammalian cloning by splitting an early embryo or nuclear transfer into oocytes method has been successfully performed. Cloning is now also possible using adult somatic cells. Although it has now been 15 years since the first cloned mammals were generated from somatic cells using nuclear transfer (NT), the success rate for producing live offspring by cloning is lo...

Background: In the last few years, a marked decrease in male fertility has been reported. Environmental factors were recently suspected for this problem. The misuse of medicines especially antibiotics are among environmental factors that can affect reproductive system. Ciprofloxacin is a synthetic antibacterial agent belonging to the family of fluoroquinolones with a very broad spectrum effect ...

background: polycystic ovarian syndrome (pcos) is one of the most common endocrine disorders which cause anovulatory infertility and hyperandrogenism in young women. the common feature in pcos women is increased ovarian androgen secretion which can effect on the prevalence of miscarriage rate. objective: the aim of this study was to investigate the effect of pcos patient's serum on in vitro dev...