Plant-derived cannabinoids, including Delta9-tetrahydrocannabinol (THC), induce apoptosis in leukemic cells, although the precise mechanism remains unclear. In the current study, we investigated the effect of THC on the upstream and downstream events that modulate the extracellular signal-regulated kinase (ERK) module of mitogen-activated protein kinase pathways primarily in human Jurkat leukem...

We explore the use of the Spiral Array spatial visualization of tonal evolution through time for the visual analysis of P.D.Q. Bach’s The ShortTempered Clavier. In particular, we analyze situations in which we can see some of the humour devices abstracted in an earlier study by David Huron. We conclude that although we can see a good number of Schickele’s humour devices − such as incongruent st...

We demonstrate that deregulation in the form of vertical separation of network components into natural monopoly and potentially competitive markets does not truly represent a lessening of regulatory burdens. That is, vertical separation is not synonymous with deregulation; “more competitors” is not equivalent to “more competition”. We assume a public interest regulator that is constrained to se...

This paper extends the political agency approach to an environment in which voting may be divided between informed and instrumental, informed and ‘expressive’ and uninformed due to ‘rational irrationality’. It constructs a model where politicians may be good, bad or populist. Initially the existence of only good and populist politicians is assumed and the incentives for good politicians to pool...

This study aimed to investigate the effect of fraction resulted of bad news on stock returns emphasizing the regulatory power of information disclosure policies that for this goal, the study population is consisted of the companies listed on the Tehran Stock Exchange during a five years' period (2010-2014). Data of selected statistical sample using systematic elimination method has been collect...

Phosphorylation of the BH3 (Bcl-2 homology domain 3)-only protein BAD (Bcl-2/Bcl-X(L)-antagonist, causing cell death) can either directly disrupt its association with the pro-survival proteins Bcl-X(L) and/or Bcl-2, or cause association of BAD with 14-3-3 proteins. In the present study, we further characterize phosphorylation of BAD at Ser170, a unique site with unclear function. We provide fur...