نتایج جستجو برای: bacterium inhibitor
تعداد نتایج: 257031 فیلتر نتایج به سال:
inhibitor development is a lifelong challenge for patients with bleeding disorders who received replacement therapy. most commonly, inhibitor formation was observed in hemophilia a patients but patients with rare bleeding disorders (rbd) especially patients with deficiency of factor xiii (fxiii) and factor v (fv) can develop an inhibitor against exogenous factors. several factors considered as ...
in this study, the neutral monosaccharide composition of the extracellular polysaccharide (eps), extracted from thermal bacillus, was determined by liquid chromatography-mass spectrometry and high performance liquid chromatography. our analysis indicated that the eps consisted of rhamnose, mannose, galactose, glucose, fructose, arabinose and xylose. in addition to the neutral sugars in the eps,...
conclusions the findings of the current study indicate that at high concentrations of salt, the growth of bacteria reduces so that it stops at a concentration of 50 mg l-1 (5%). thus, the bacterium is halotolerant or halophilic. with an increase in phenol concentration, the growth rate increased. phenol toxicity appears at a concentration of 600 mg l-1. results the phenol concentration of 600 m...
background toluene is a cyclic aromatic hydrocarbon which is widely used as an industrial feedstock and as a solvent. it is one of the major parts of pollution in oil-contaminated environments. objectives the main aim of this study was to isolate and characterize a bacterium with high potential application in toluene bioremediation. materials and methods to isolate a toluene-degrading bacterium...
codon optimization, cloning and expression of the human leukemia inhibitory factor (hlif) in e. coli
background: leukemia inhibitor factor (lif) is a very important pleiotropic cytokine which belongs to interleukin-6 (il-6) family. lif exerts multiple effects on different types of cells and tissues with numerous regulatory effects in vivo and in vitro. it is a lymphoid factor, which performs a number of activities including cholinergic neuron differentiation, control of stem cell pluripotency...
Sialidase catalyzes the removal of a terminal sialic acid from glycoconjugates and plays a pivotal role in nutrition, cellular interactions and pathogenesis mediating various infectious diseases including cholera, influenza and sepsis. An array of antiviral sialidase agents have been developed and are commercially available, such as zanamivir and oseltamivir for treating influenza. However, the...
An important facet of the Staphylococcus aureus host-pathogen interaction is the ability of the invading bacterium to evade host innate defenses, particularly the cocktail of host antimicrobial peptides. In this work, we showed that IsdA, a surface protein of S. aureus which is required for nasal colonization, binds to lactoferrin, the most abundant antistaphylococcal polypeptide in human nasal...
The X-linked inhibitor of apoptosis protein (XIAP) is a potent caspase inhibitor, best known for its anti-apoptotic function in cancer. During apoptosis, XIAP is antagonized by SMAC, which is released from the mitochondria upon caspase-mediated activation of BID. Recent studies suggest that XIAP is involved in immune signaling. Here, we explore XIAP as an important mediator of an immune respons...
Natural products represent valuable lead structures for drug discovery. However, for most bioactive compounds no cellular target is yet identified and many substances predicted from genome analysis are inaccessible due to their life stage-dependent biosynthesis, which is not reflected in common isolation procedures. In response to these issues, an NMR-based and target-directed protease assay fo...
Tuberculosis (TB), resulting from infection with the bacterium Mycobacterium tuberculosis (M. tb), is a resurgent and major worldwide health problem. TB was the principal cause of early death in Europe in the 17th and 18th centuries, and was still a greatly feared disease in the 19th and early part of the 20th century (the “white plague”), when there was no active treatment available. Yet by th...
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