We describe a multicellular approach to control target cell population endowed with bistable toggle-switch. The idea is engineer synthetic microbial consortium consisting of three different populations. In such consortium, two populations, the Togglers, responding some reference input, can induce switch memory mechanism in third population, Targets, so as activate or deactivate additional funct...

The intrinsic biodegradability of hydrocarbons and the distribution of proficient degrading microorganisms in the environment are very crucial for the implementation of bioremediation practices. Among others, one of the most favorable methods that can enhance the effectiveness of bioremediation of hydrocarbon-contaminated environment is the application of biosurfactant producing microbes. In th...

Polychlorinated biphenyls (PCBs) are widespread persistent pollutants that cause several adverse health effects. Aerobic bioremediation of PCBs involves the activity of either one bacterial species or a microbial consortium. Using multiple species will enhance the range of PCB congeners co-metabolized since different PCB-degrading microorganisms exhibit different substrate specificity. We have ...

phenol and its homologues are aromatics containing hydroxyl, methyl, amide and sulphonic groups attached to the benzene ring. these molecules are both anthropogenic and xenobiotics. phenols are environmental pollutants discharged through wastewaters from various industries. phenols are toxic to several biochemical reactions. however biological transformation of phenols to non-toxic entities exi...

background: amoxicillin is widely used as an antibiotic in the modern medicine. due to its chemical structure, polarity, activity level, antibiotic specifications, and environmental sustainability, amoxicillin leaks into the groundwater, surface waters, and drinking water wells. many physical and chemical methods have been suggested for removing amoxicillin from aquatic environments. however, t...

The low number and activity of hydrocarbon-degrading bacteria and the low solubility and availability of hydrocarbons hamper bioremediation of oil-contaminated soils in arid deserts, thus bioremediation treatments that circumvent these limitations are required. We tested the effect of Ethylenediaminetetraacetic acid (EDTA) addition, at different concentrations (i.e. 0.1, 1 and 10 mM), on bacter...

Biodegradation of pollutants in the environment is directly affected by microbial communities and pollutant mixture at site. Lab experiments using bacterial consortia substrate mixtures are required to increase our understanding these processes environment. One deficiencies working with environmental cultures inability culture identify active strains while knowing they representative original I...