نتایج جستجو برای: bacterial barrier

تعداد نتایج: 291925  

2017
Fitua Al-Saedi Diana Pereira Vaz Daniel H Stones Anne Marie Krachler

Bacterial adhesion to host receptors is an early and essential step in bacterial colonization, and the nature of adhesion-receptor interactions determines bacterial localization and thus the outcome of these interactions. Here, we determine the host receptors for the Multivalent Adhesion Molecule from the gut commensal E. coli HS (MAM), which contains an array of seven mammalian cell entry (MCE...

Journal: :Blood purification 2011
Eberhard Ritz

The recent interest in the role of the intestine in the cardiovascular stability of uremic patients, specifically on dialysis, but potentially also in chronic kidney disease, must be seen against the background of the recent great interest in the role of the gut in chronic heart failure [Curr Opin Clin Nutr Metab Care 2008;11:632-639]. There has been a long-standing interest in the role of the ...

2018
Shui-Xing Yu Wei Chen Zhen-Zhen Liu Feng-Hua Zhou Shi-Qing Yan Gui-Qiu Hu Xiao-Xia Qin Jie Zhang Ke Ma Chong-Tao Du Jing-Min Gu Xu-Ming Deng Wen-Yu Han Yong-Jun Yang

The intestinal mucosal barrier is critical for host defense against pathogens infection. Here, we demonstrate that the mixed lineage kinase-like protein (MLKL), a necroptosis effector, promotes intestinal epithelial barrier function by enhancing inflammasome activation. MLKL-/- mice were more susceptible to Salmonella infection compared with wild-type counterparts, with higher mortality rates, ...

2013
Rudolf Lucas Istvàn Czikora Supriya Sridhar Evgeny A. Zemskov Aluya Oseghale Sebastian Circo Stephen D. Cederbaum Trinad Chakraborty David J. Fulton Robert W. Caldwell Maritza J. Romero

The integrity of epithelial and endothelial barriers in the lower airspaces of the lungs has to be tightly regulated, in order to prevent leakage and to assure efficient gas exchange between the alveoli and capillaries. Both G(-) and G(+) bacterial toxins, such as lipopolysaccharide and pneumolysin, respectively, can be released in high concentrations within the pulmonary compartments upon anti...

2014
Jenson Lim Daniel H. Stones Catherine Alice Hawley Charlie Anne Watson Anne Marie Krachler Guy Tran Van Nhieu

Vibrio parahaemolyticus is an emerging bacterial pathogen which colonizes the gastrointestinal tract and can cause severe enteritis and bacteraemia. During infection, V. parahaemolyticus primarily attaches to the small intestine, where it causes extensive tissue damage and compromises epithelial barrier integrity. We have previously described that Multivalent Adhesion Molecule (MAM) 7 contribut...

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