objective: helicobacter pylori has a well-established role in the development of gastric cancer. in vitro studies reveal increased proliferation of the gastric mucosa in the presence of h. pylori infection. it has been also shown that production of some cytokines, such as interleukin-1 beta (il-1b) is increased in h. pylori infection. in addition, il-1b increases proliferation of gastric epithe...

background the mutations of lhbs in pre-s, especially in pre-s2, are definitive in hepatocellular carcinoma (hcc) associated with hbv. however, the mechanisms of the n-glycosylation modification in lhbs are unclear. the n-glycosylation modification of lhbs affects endoplasmic reticulum stress, cell proliferation and its secretion which was further studied. objectives the objectives of our studi...

background although it is life-saving, blood transfusion therapy has resulted in risk for transfusion-transmitted infections (ttis) in the majority of sickle cell anemia being patients. objectives the current study aimed to determine the prevalence of hbv, hcv and different genotypes of hcv among sickle cell anemia (sca) patients in ahvaz city, south-western iran. materials and methods a cross-...

Background and Objective: Oxidative stress induced by proinflammatory cytokines such as IL-1β plays a major role in β-cell destruction in diabetes type 1. Salvianolic acid B (Sal B) is a polyphenolic compound with antioxidant and protective effects. Thus, objective of this study was to assess the protection exerted by Sal B on isolated rat islets exposed to IL-1β and to investigate an underlyin...

Whole-cell pertussis vaccine (wP) has been imperative and highly effective in preventing childhood deaths due to pertussis. Pertussis toxin is one of the virulence factors of Bordetella pertussis in all available pertussis vaccines. wP production in Razi Vaccine and Serum Research Institute is according to bioreactor culture of B. pertussis strains in B2 medium. The aim ...