نتایج جستجو برای: b abortus

تعداد نتایج: 902005  

Journal: :Infection and immunity 1979
C G Lee P W Ladds D L Watson M E Goddard

Two irritants, phosphate-buffered saline and alcohol, and antigens including killed Brucella abortus, live B. abortus, Staphylococcus aureus, and rat parvovirus were separately infused into rat mammary glands during pregnancy, and by using immunofluorescent techniques, the numbers of immunoglobulin-containing cells in glands during lactation and involution were determined. The study provided ba...

2018
Woo Bin Park Young Bin Im Soojin Shim Han Sang Yoo

Brucella abortus is a bacterium that causes brucellosis and is the causative agent of worldwide zoonoses. Pathogenesis of the B. abortus infection is complicated, and several researchers have attempted to elucidate the infection mechanism of B. abortus. While several proteins have been revealed as pathogenic factors by previous researchers, the underlying mechanism of B. abortus infection is un...

Journal: :Journal of wildlife diseases 2009
Pauline Nol Steven C Olsen Jack C Rhyan

A previous investigation of the safety of Brucella abortus strain RB51 (sRB51) in various nontarget species suggested that Richardson's ground squirrels (Spermophilus richardsonii) may develop persistent infections when orally inoculated with the vaccine. In the present study, sRB51, B. abortus strain 19 (s19), and virulent B. abortus strain 9941 (s9941) were administered orally to Richardson's...

Journal: :Iranian journal of immunology : IJI 2014
Mohsen Mohammadi Zahra Kianmehr Sussan Kaboudanian Ardestani Behnaz Gharegozlou

BACKGROUND Adjuvants are used to increase the immunogenicity of new generation vaccines, especially those based on recombinant proteins. Despite immunostimulatory properties, the use of bacterial lipopolysaccharide (LPS) as an adjuvant has been hampered due to its toxicity and pyrogenicity. Brucella abortus LPS is less toxic and has no pyrogenic properties compared to LPS from other gram negati...

Journal: :FEMS microbiology letters 2015
Lauren Togonon Arayan Hannah Leah Simborio Alisha Wehdnesday Bernardo Reyes Huynh Tan Hop WonGi Min Hu Jang Lee Man Hee Rhee Hong Hee Chang Suk Kim

This study indicated that RGSF-A caused a marked reduction in the adherence, internalization and intracellular growth of Brucella abortus in RGSF-A-treated cells. Furthermore, a decline in the intensity of F-actin fluorescence was observed in RGSF-A-treated cells compared with untreated B. abortus-infected cells. In addition, an evaluation of phagocytic signaling proteins by Western blot analys...

2007
Cevat NİSBET Gül Fatma YARIM Alper ÇİFTCİ Sena ÇENESİZ Gülay ÇİFTCİ

The objective of this study was to determine serum nitric oxide (NO) and malondialdehyde (MDA) levels in cattle infected with Brucella abortus (B. abortus). Study cohort was comprised of 30 cattle aged between 2-3 years; 20 infected with B. abortus and 10 healthy cattle. B. abortus infection was determined in the animals by Serum Agglutination Test and Multiplex PCR assay. Serum NO level was de...

Journal: :Infection and immunity 2005
R Adone F Ciuchini C Marianelli M Tarantino C Pistoia G Marcon P Petrucci M Francia G Riccardi P Pasquali

Vaccination against Brucella infections in animals is usually performed by administration of live attenuated smooth B. abortus strain S19 and B. melitensis strain Rev1. They are proven effective vaccines against B. abortus in cattle and against B. melitensis and B. ovis in sheep and goats, respectively. However, both vaccines have the main drawback of inducing O-polysaccharide-specific antibodi...

2017
M Ayelén Milillo Lis N Velásquez Aldana Trotta M Victoria Delpino Fábio V Marinho Luciana Balboa Mónica Vermeulen Sonia L Espindola Nahuel Rodriguez-Rodrigues Gabriela C Fernández Sergio Costa Oliveira Guillermo H Giambartolomei Paula Barrionuevo

Despite eliciting a potent CD8+ T cell response, Brucella abortus is able to persist and establish a chronic infection inside its host. We have previously reported that the infection of human monocytes/macrophages with B. abortus inhibits the IFN-γ-induced MHC-I cell surface expression down-modulating cytotoxic CD8+ T cell responses. MHC-I down-modulation depends on bacterial viability and resu...

2016
Gamal Wareth Murat Eravci Christoph Weise Uwe Roesler Falk Melzer Lisa D. Sprague Heinrich Neubauer Jayaseelan Murugaiyan

Brucellosis is a debilitating zoonotic disease that affects humans and animals. The diagnosis of brucellosis is challenging, as accurate species level identification is not possible with any of the currently available serology-based diagnostic methods. The present study aimed at identifying Brucella (B.) species-specific proteins from the closely related species B. abortus and B. melitensis usi...

2016
Jianpeng Gao Mingxing Tian Yanqing Bao Peng Li Jiameng Liu Chan Ding Shaohui Wang Tao Li Shengqing Yu

Brucellosis, caused by a facultative intracellular pathogen Brucella, is one of the most prevalent zoonosis worldwide. Host infection relies on several uncanonical virulence factors. A recent research hotpot is the links between carbon metabolism and bacterial virulence. In this study, we found that a carbon metabolism-related pyruvate kinase (Pyk) encoded by pyk gene (locus tag BAB_RS24320) wa...

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