نتایج جستجو برای: azoles

تعداد نتایج: 1992  

Journal: :Molecular pharmacology 2013
Natalia Mast Wenchao Zheng C David Stout Irina A Pikuleva

Although there are currently three generations of antifungal azoles on the market, even the third-generation agents show undesirable interactions with human cytochrome P450 (P450) enzymes. CYP46A1 is a cholesterol-metabolizing P450 in the brain that tightly binds a number of structurally distinct azoles. Previously, we determined the crystal structures of CYP46A1 in complex with voriconazole an...

Journal: :Memorias do Instituto Oswaldo Cruz 2003
Priscilla de Laet Sant'Ana Mariano Eveline Pípolo Milan Daniel Archimedes da Matta Arnaldo Lopes Colombo

We investigated the presence of Candida dubliniensis among isolates previously identified as Candida albicans and maintained in a yeast stock collection from 1994 to 2000. All isolates were serotyped and further evaluated for antifungal susceptibility profile. After doing a screening test for C. dubliniensis isolates based on the capability of colonies to grow at 42 C, its final identification ...

Journal: :Antimicrobial Agents and Chemotherapy 2021

Invasive yeast infections represent a major global public health issue, and only few antifungal agents are available. Azoles one of the classes antifungals used for treatment invasive candidiasis. The determination susceptibility profiles using standardized methods is important to identify resistant isolates uncover potential emergence intrinsically species.

2017
Heather A. Howell Wescott David M. Roberts Christian L. Allebach Rachel Kokoczka Tanya Parish

Azoles are a class of antimicrobial drugs used clinically to treat yeast and fungal infections. Against pathogenic yeast and fungi, azoles act by inhibiting the activity of the cytochrome P450 Cyp51, which is involved in the synthesis of a critical component of the yeast and fungal cell membrane. Azoles have antibacterial activity, including against mycobacteria, but the basis for this activity...

Journal: :Organic & biomolecular chemistry 2010
Mahiuddin Baidya Frank Brotzel Herbert Mayr

The kinetics of the reactions of some imidazoles, benzimidazoles and benzotriazoles with benzhydrylium ions (diarylcarbenium ions) have been studied photometrically in DMSO, acetonitrile, and aqueous solution at 20 degrees C. The resulting second-order rate constants have been used to determine the nucleophile-specific parameters N and s of these azoles according to the linear-free-energy relat...

Journal: :Eukaryotic cell 2011
Ying-Lien Chen Alexandra Brand Emma L Morrison Fitz Gerald S Silao Ursela G Bigol Fedelino F Malbas Jeniel E Nett David R Andes Norma V Solis Scott G Filler Anna Averette Joseph Heitman

Candida dubliniensis is an emerging pathogenic yeast species closely related to Candida albicans and frequently found colonizing or infecting the oral cavities of HIV/AIDS patients. Drug resistance during C. dubliniensis infection is common and constitutes a significant therapeutic challenge. The calcineurin inhibitor FK506 exhibits synergistic fungicidal activity with azoles or echinocandins i...

Journal: :Biological & pharmaceutical bulletin 2012
Wenqiang Chang Ying Li Li Zhang Aixia Cheng Yongqing Liu Hongxiang Lou

Candida albicans is one of the most prevalent human opportunistic pathogens. C. albicans undergoes a yeast-to-hyphal transition that has been identified as a virulence factor as well as a critical element for mature biofilm formation. A previous study in our lab showed retigeric acid B (RAB), a lichen derived pentacyclic triterpenoid, displayed synergistic antifungal activity with azoles. We no...

Journal: :Journal of Synthetic Organic Chemistry, Japan 1987

Journal: :Clinical Infectious Diseases 2019

Journal: :Antimicrobial Agents and Chemotherapy 2014

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