The Wittig reaction rate can be dramatically enhanced by irradiation of the reaction mixture containing an aldehyde or ketone; methoxymethyl(triphenyl)phosphonium chloride, potassium t-butoxide, and t BuOH with a commercial microwave oven. Carbonyl compound are converted to Witting products within three min. in good yields.

Trinuclear rare-earth-metal methylidene (CH2 2−) complexes are an emerging class of compounds that serve as methylidene transfer agents for methylenation of carbonyl compounds. Herein, the reaction of a trinuclear scandium methylidene complex with acetophenone was used as a model reaction of the multimetallic-cooperating methylidene transfer case, and its detailed mechanism has been investigate...

This communication reports the first use of the Wittig reaction to produce alkenylcarbaboranes.

An efficient three-component reaction of dialkyl acetylendicarboxylates and 2-Pyrrolidin in the presence of triphenylphosphine produces dialkyl 2-(2-Pyrrolidin-N-yl)-3-(triphenylphosphanylidene)succinate. These phosphoranes undergo mild intramolecular Wittig reaction to produce dialkyl (E)-2-(4,5-dihydro-3H-pyrrol-2-yl)fumarate in excellent yields.

Key words (–)-peyssonnoside A - diterpene glycoside marine natural product antimicrobial dearomative cyclization HAT-initiated Wittig reaction Mukaiyama hydration

Stilbene and phenylethynylstilbene units are excellent candidates for fluorescent sensor synthesis. In this paper we show a fast efficient method the preparation of fluorophores based on biphenyl nuclei with phenylene-vinylene functionalized by donor groups. Using pallado catalysed coupling reactions Sonogashira types Wittig or Wittig-Horner reaction, stilbene phenylethylsilbene arms O-alkyl N-...

Bioorthogonal reactions are chemical reactions that neither interact with nor interfere with a biological system. The participating functional groups must be inert to biological moieties, must selectively reactive with each other under biocompatible conditions, and, for in vivo applications, must be nontoxic to cells and organisms. Additionally, it is helpful if one reactive group is small and ...

The cis-trans ratio of the alkenes formed in Wittig reactions of semistabilised ylides (derived from benzyltriarylphosphonium salts in ethanolic sodium ethoxide) with benzaldehyde, acetaldehyde or trimethylacetaldehyde increases as steric crowding at phosphorus increases. In contrast, the cis-trans ratio of the unsaturated esters formed in the related reactions of the stabilised ethoxycarbonylm...