This survey to detect anthelmintic resistance in nematode parasites of sheep was conducted on 11 farms in the Occidental and 26 farms in the Oriental Regions of Paraguay using the faecal egg count reduction test (FECRT). The anthelmintic groups tested were the benzimidazoles, levamisole and avermectins (both oral and injectable). Overall the levels of resistance were 73%, 68%, 73% and 47%, resp...

Avermectins are a group of macrocyclic lactones that commonly used as pesticides to treat pests and parasitic worms. Some members the avermectin family, such ivermectin, have been found exhibit anti-proliferative activity toward cancer cells. This study aimed investigate potential anti-cancer activities B1a using HCT-116 colon cell line. The MTT assay was calculate IC50 by incubating cells with...

A simple and selective assay system was developed in the search for new insecticidal substances from Actinomycetales strains propagated on solid culture media. The strains were first tested for their ability to produce antimicrobial compounds. Only strains displaying weak or no activity were retained and screened in the insecticidal bioassay. Microbial solid cultures were given as food to larva...

Three isolates of Haemonchus contortus selected for avermectin resistance in sheep were compared in three in vitro pharmacological tests previously shown to discriminate between field isolates of H. contortus resistant and susceptible to the avermectins. Two isolates, F7-A and IVC, were selected for avermectin resistance in the laboratory from a reference susceptible isolate using suboptimal do...

Ectoparasites present a global challenge to animal health, affecting wide range of species. These parasites can infect both animals and humans, leading significant health issues. The impact ectoparasites extends beyond as they also reduce the productivity livestock. Moreover, many ectoparasite species act vectors for bacterial, viral, or parasitic pathogens, thereby posing risks human health. H...