Migraine is a disabling common brain disorder typically characterized by attacks of severe headache and associated with autonomic and neurological symptoms. Its etiology is far from resolved. This review will focus on evidence that epigenetic mechanisms play an important role in disease etiology. Epigenetics comprise both DNA methylation and post-translational modifications of the tails of hist...

The dual mission of the Wisconsin Initiative for Science Literacy is to promote literacy in science, mathematics and technology among the general public and to attract future generations to careers in research, teaching and public service. At the March 5, 2010 UW-Madison Chemistry Department Colloquium, Prof. Bassam Z. Shakhashiri, the director of the Wisconsin Initiative for Science Literacy (...

While usually been considered by established businesses as an attack, disruptive innovation provide an appropriate innovation approach for SMEs through new market discovery. This article tries to explore the opportunities offered by disruptive technlology and how SMEs could benefit from diruptive innovation. The process and features of diruptive innovaion and a managrial framework for diruptive...