A female patient developed avascular necrosis of the femoral heads after receiving low doses of glucocorticosteroids (GC) for 3 months. Genotyping of the GC receptor (GR) showed that she was heterozygous for the Bcl-1 allele and heterozygous for the N363S allele. Interestingly, these GR variants are both associated with higher sensitivity to glucocorticoids. It is not known whether the GR gene ...

BACKGROUND AND PURPOSE No prior report has comprehensively discussed the intravertebral vacuum cleft sign and the fluid sign on MR images of vertebral osteonecrosis. The purpose of this study was to investigate MR images of osteonecrotic vertebral bodies and adjacent intervertebral disks and vertebral bodies. METHODS We retrospectively reviewed MR images of patients with vertebral osteonecros...

Osteonecrosis of the femoral head occurs predominantly in younger patients, and without treatment most of them suffer from collapse of the femoral head and painful arthritis of the hip joint within several years. The ideal goal of early treatment is to delay or arrest the progression of the disease before articular collapse occurs. It has been well documented that without specific treatment app...

Background. This study was aimed at investigating the pathogenesis of oxidative stress in steroid-induced avascular necrosis of the femoral head (SANFH) and at exploring the mechanism and protective effects of Panax notoginseng saponins (PNS) on early SANFH. Methods. 80 adult New Zealand rabbits were randomly divided into control group, model group, and PNS group. In model group, equine serum w...

Dott. Massimo Bertoli, Riviera S. Benedetto, 124, I-35100 Padova (Italy) Dear Sir, Aseptic osteonecrosis of the femur head, a disabling disease which strikes about 16% of renal transplant recipients, seems clearly related to steroid therapy as its incidence drops sharply with the use of new immunosuppres-sants such as cyclosporin [1]. Several etiological factors related to corticosteroid treatm...

In this review, we explored the progress of the pathogenesis of Kümmell's disease intravertebral vacuum. Using different expressions of the same disease including 'Kümmell's disease', 'avascular necrosis after vertebral compression fracture (VCF)', 'post-traumatic vertebral osteonecrosis', 'vertebral pseudarthrosis', 'intravertebral vacuum (cleft or gas)', 'delayed vertebral collapse', 'VCF non...

Avascular necrosis of femoral head is not an uncommon chronic disorder of hip in adults. The patient presents to the health facility with varied range of symptoms based on the degree of collapse of the head and arthritic changes at hip. Avascular necrosis of hip presenting as subacute condition with pathological sub capital neck of femur fracture has not yet been reported. The commonly used Fic...

Background. The most severe type of injuries the proximal epiphysis humerus are intraarticular fractures. One main complication is development avascular osteonecrosis, which caused by peculiarities blood supply humeral head and its compromised vascularization as a result trauma. Current osteosynthesis techniques for fractures (PH) do not reduce risk osteonecrosis (AONHH) nonunion. To prevent is...

Background: Femoral head avascular necrosis is the cause of paralyzing status of youth population. Initial diagnosisis the main element in treating the disease. Bone grafting and core decompression are the approved cures at the earlysteps of the disease. Hip replacement in a total manner is the common cure in the final stages. The optimal treatment inthe intermediate stages is...