نتایج جستجو برای: autoantibody

تعداد نتایج: 6541  

2005
Peter Berchtold George L. Dale Patricia Tani Robert McMillan

Intravenous immunoglobulin (lVlgG) causes an acute rise in the platelet count in the majority of patients with chronic immune thrombocytopenic purpura (ITP) but the mechanism(s) of action is still unknown. We evaluated the ability of three different IVIgG preparations to inhibit the in vitro binding of autoantibody to platelet glycoprotein (GP) llb/ lila. ITP plasma. known to contain anti-GPIIb...

Journal: :Cancer research 2013
Jon J Ladd Timothy Chao Melissa M Johnson Ji Qiu Alice Chin Rebecca Israel Sharon J Pitteri Jianning Mao Mei Wu Lynn M Amon Martin McIntosh Christopher Li Ross Prentice Nora Disis Samir Hanash

We assessed the autoantibody repertoire of a mouse model engineered to develop breast cancer and the repertoire of autoantibodies in human plasmas collected at a preclinical time point and at the time of clinical diagnosis of breast cancer. In seeking to identify common pathways, networks, and protein families associated with the humoral response, we elucidated the dynamic nature of tumor antig...

2017
Ralf J. Ludwig Karen Vanhoorelbeke Frank Leypoldt Ziya Kaya Katja Bieber Sandra M. McLachlan Lars Komorowski Jie Luo Otavio Cabral-Marques Christoph M. Hammers Jon M. Lindstrom Peter Lamprecht Andrea Fischer Gabriela Riemekasten Claudia Tersteeg Peter Sondermann Basil Rapoport Klaus-Peter Wandinger Christian Probst Asmaa El Beidaq Enno Schmidt Alan Verkman Rudolf A. Manz Falk Nimmerjahn

Autoantibodies are frequently observed in healthy individuals. In a minority of these individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis or Graves' disease. Overall, more than 2.5% of the population is affected by autoantibody-driven autoimmune disease. Pathways leading to autoantibody-induced pathology greatly differ among different diseases, and autoa...

2008
S Lester C McLure J Williamson P Bardy M Rischmueller R L Dawkins

OBJECTIVE The RCA alpha block (Regulators of Complement Activation, 1q32) contains critical complement regulatory genes such as CR1 and MCP. This study examined RCA alpha block haplotype associations with both disease susceptibility and diversification of the anti-Ro/La autoantibody response in primary Sjögren syndrome (pSS). METHODS 115 patients with pSS and 98 controls were included in the ...

2010
Ann W Morgan James I Robinson Philip G Conaghan Stephen G Martin Elizabeth MA Hensor Michael D Morgan Lori Steiner Henry A Erlich Hock-Chye Gooi Anne Barton Jane Worthington Paul Emery

INTRODUCTION This study investigated five confirmed rheumatoid arthritis (RA) susceptibility genes/loci (HLA-DRB1, PTPN22, STAT4, OLIG3/TNFAIP3 and TRAF1/C5) for association with susceptibility and severity in an inception cohort. METHODS The magnitude of association for each genotype was assessed in 1,046 RA subjects from the Yorkshire Early RA cohort and in 5,968 healthy UK controls. Additi...

2017

The association of systemic lupus erythematosus (SLE) with autoimmune hemolytic anemia (AIHA) is a known phenomenon. In many cases of AIHA, no autoantibody specificity is present. The patient’s serum reacts with all of the red blood cell (RBC) samples tested and the autoantibody appears to have broad specificity in the Rh blood group system. Occasionally, RBC autoantibodies demonstrate apparent...

2017

The association of systemic lupus erythematosus (SLE) with autoimmune hemolytic anemia (AIHA) is a known phenomenon. In many cases of AIHA, no autoantibody specificity is present. The patient’s serum reacts with all of the red blood cell (RBC) samples tested and the autoantibody appears to have broad specificity in the Rh blood group system. Occasionally, RBC autoantibodies demonstrate apparent...

2017

The association of systemic lupus erythematosus (SLE) with autoimmune hemolytic anemia (AIHA) is a known phenomenon. In many cases of AIHA, no autoantibody specificity is present. The patient’s serum reacts with all of the red blood cell (RBC) samples tested and the autoantibody appears to have broad specificity in the Rh blood group system. Occasionally, RBC autoantibodies demonstrate apparent...

2017

The association of systemic lupus erythematosus (SLE) with autoimmune hemolytic anemia (AIHA) is a known phenomenon. In many cases of AIHA, no autoantibody specificity is present. The patient’s serum reacts with all of the red blood cell (RBC) samples tested and the autoantibody appears to have broad specificity in the Rh blood group system. Occasionally, RBC autoantibodies demonstrate apparent...

Journal: :Clinical and experimental immunology 1977
A Cooke J H Playfair

Strain differences in ease of induction of autoantibody production were observed when mice were injected with rat RBC. Responsiveness was not linked to the H-2 locus. NZB and (NZB X BALB/c)F1 mice were hyper-responsive both in terms of the induction of autoantibody and in the production of agglutinating antibody to rat RBC. C57BL/c and (C57BL X BALB/c)F1 were poor responders. Injection of the r...

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