A series of molecular adsorbates having various chain lengths of terminal poly(ethylene glycol methyl ether) (PEG) moieties, thiol head groups, and intervening free radical initiator moieties was used to functionalize the surface of gold nanoparticles (AuNPs). The bulky PEG groups stabilized the functionalized AuNPs by providing steric hindrance against AuNP aggregation, such aggregation being ...

Gold nanoparticles (AuNPs) are excellent tools for cancer cell imaging and basic research. However, they have yet to reach their full potential in the clinic. At present, we are only beginning to understand the molecular mechanisms that underlie the biological effects of AuNPs, including the structural and functional changes of cancer cells. This knowledge is critical for two aspects of nanomed...

The preparation of gold nanoparticles (AuNPs) involves a variety of chemical and physical methods. These methods use toxic and environmentally harmful chemicals. Consequently, the synthesis of AuNPs using green chemistry has been under investigation to develop eco-friendly nanoparticles. One approach to achieve this is the use of plant-derived phytochemicals that are capable of reducing gold io...

With a sharp increase in the cases of multi-drug resistant (MDR) bacteria all over the world, there is a huge demand to develop a new generation of antibiotic agents to fight them. As an alternative to the traditional drug discovery route, we have designed an effective antibacterial agent by modifying an existing commercial antibiotic, kanamycin, conjugated on the surface of gold nanoparticles ...

Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its agonistic receptors have been identified as highly promising antitumor agents preferentially eliminating cancer cells with minimal damage, the emergence of TRAIL resistance in most cancers may contribute to therapeutic failure. Thus, there is an urgent need for new approaches to overcome TRAIL resistance. Gold nano...

We report a novel approach for preparation of networked gold nanoparticles (AuNPs) using reactive oxygen species (i.e., peroxymonocarbonate, HCO(4)(-)) as a novel reducing agent, along with nonionic fluorosurfactant (FSN) assistance. The formation mechanism of the networked AuNPs is demonstrated by transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM),...

We herein report that the adsorption/desorption of citrate-capped gold nanoparticles (AuNPs) transiently causes leakage in fluid phase DOPC liposomes, while the liposomes do not leak with AuNPs capped with mercaptopropionic acid (MPA). Leakage also fails to occur for gel phase DPPC liposomes. Citrate-capped (but not MPA-capped) AuNPs raise the phase transition temperature of DPPC. We conclude t...

Poplar plants (Populus deltoides × nigra, DN-34) were used as a model to explore vegetative uptake of commercially available gold nanoparticles (AuNPs) and their subsequent translocation and transport into plant cells. AuNPs were directly taken up and translocated from hydroponic solution to poplar roots, stems and leaves. Total gold concentrations in leaves of plants treated with 15, 25 and 50...

Nanotechnology is recently emerging in various fields especially in biomedical applications as many pathogenic organisms are gaining resistant against available antibiotics. In the present study, we have synthesized biocompatible therapeutic gold nanoparticles using Brevibacillus formosus isolated from the Hutti gold mine, India. Gold nanoparticles (AuNPs) synthesised by the reduction of gold c...

Objective (s): In light of misuse of antibiotics in animal husbandry and their side effects on human health, there is an argent need to develop simple and rapid methods for determining the quantification of antibiotics in biological systems. Materials and Methods: In this work a facile and ultrasensitive colorimetric aptasensor was reported for detection of oxytetracycline (OTC) in water and mi...