Noise-induced cochlear synaptopathy has been demonstrated in numerous rodent studies. In these animal models, the disorder is characterized by a reduction in amplitude of wave I of the auditory brainstem response (ABR) to high-level stimuli, whereas the response at threshold is unaffected. The aim of the present study was to determine if this disorder is prevalent in young adult humans with nor...

The recent discovery of the contribution of alpha synuclein in the auditory system prompted further investigation of its functional role. Auditory brainstem response (ABR) and gap detection testing were completed on wild-type and transgenic M83 mice to assess the role of alpha synuclein in noise-induced hearing loss and central auditory function. Copyright by Melissa E. Mooney 2010

Individuals with sensorineural hearing loss often report frustration with speech being loud but not clear, especially in background noise. Despite advanced digital technology, hearing aid users may resort to removing their hearing aids in noisy environments due to the perception of excessive loudness. In an animal model, sensorineural hearing loss results in greater auditory nerve coding of the...

Objectives: The result of auditory brainstem response is used worldwide for detecting hearing impairments or hearing aids. This study aimed to introduce the superiority of mathematical innovation algorithm toward subjective evaluation by an audiologist. The automatic algorithm method is encouraged for detecting the waves of Auditory Brainstem Response (ABR), because it can reduce subjective eva...

OBJECTIVE It has been shown that oxidative stress plays an important role in development of noise induced hearing loss. Since static magnetic fields (SMF) exposure may alter dynamics of oxidative processes in the tissue, the aim of the study was to assess the influence of SMF on noise-induced alteration in the cochlear level of reactive oxygen species (ROS) and hearing thresholds. MATERIALS A...

American mink (Neovison vison) kits are born altricial and fully dependent on maternal care, for which the kits' vocalizations appear essential. We used auditory brainstem responses (ABRs) to determine: (1) hearing sensitivity of adult females from two breeding lines known to differ in maternal behaviour and (2) development of hearing in kits 8-52 days of age. We also studied sound production i...

OBJECTIVE To report on clinical experience using dichotic multiple-stimulus auditory steady-state responses (ASSRs) as an objective technique to estimate frequency-specific hearing thresholds in hearing-impaired infants. METHODS A comparison was made between the click-evoked auditory brainstem response (ABR), auditory steady-state responses and behavioral hearing thresholds (BHTs). Both ears ...

The auditory brainstem response (ABR) to clicks is widely used for early detection of hearing loss in the child at risk for hearing dysfunction, but there is a lack of direct, large-sample estimates of test accuracy. In this report, results and preliminary analyses are presented that relate click ABR thresholds obtained at 3 to 12 months corrected age to detailed follow-up behavioral puretone a...

PURPOSE To study the audiovestibular functions in cases of migraine with or without vertigo. MATERIALS AND METHODS This was a prospective study involving 50 cases of migraine who were divided into 2 groups: patients with vertigo and those without. All patients underwent a detailed otological and neurootological examination followed by full audiological and vestibular investigation including p...

This animal study was designed to determine if minocycline ameliorates cochlear damage is caused by intratympanic injection of the ototoxic aminoglycoside antibiotic neomycin. Baseline auditory-evoked brainstem responses were measured in gerbils that received 40 mM intratympanic neomycin either with 0, 1.2, or 1.5 mg/kg intraperitoneal minocycline. Four weeks later auditory-evoked brainstem res...