BACKGROUND There is increasing interest in the concept of atrial cardiomyopathy, but the underlying molecular and mechanistic determinants remain poorly defined. We identified a family with heritable atrial cardiomyopathy manifesting as progressive atrial-selective electromechanical dysfunction, tachyarrhythmias, and bradyarrhythmias requiring pacemaker implantation. Myosin light-chain 4 (MYL4)...

the conduction system. In some PCCD patients, a conduction defect is documented from birth. Depending on the consequence of the mutation on the sodium channels, the phenotype may be progressive or congenital (Table).4 If the action potential generation and/or propagation is more severely impaired in the atria than in the ventricles in SCN5A mutation patients, the sinus node dysfunction caused b...

A 64-year-old female with exertional shortness of breath and a history of mitral regurgitation with chronic atrial fibrillation (AF) underwent robotically assisted mitral valve repair (34 mm Cosgrove annuloplasty ring; Edwards Lifesciences, Irvine, CA, USA), left atrial appendage (LAA) ligation, and biatrial Maze procedure (CryoMaze; ATS Medical, Inc., Minneapolis, MN, USA). Postoperatively the...

Motion standstill is different from the usual perceptual experiences associated with objects in motion. In motion standstill, a pattern that is moving quite rapidly is perceived as being motionless, and yet its details are not blurred but clearly visible. We revisited motion standstill in dynamic random-dot stereograms similar to those first used by Julesz and Payne [Julesz B, Payne R (1968) Vi...

Objective To characterize the cardiac phenotype associated with novel pathogenic variant (c.1526del) of LMNA gene, which we identified in a large, six-generation family. Methods and Results A family tree was constructed. The clinical data living deceased members were collected. DNA samples from 7 analyzed for mutations using whole-exome high-throughput sequencing technology. presentation carrie...