Plasmodium falciparum (P. falciparum) is the main parasite known to cause malaria in humans. The antimalarial drug atovaquone inhibit Qo-site of cytochrome bc1 complex P. falciparum, which ultimately blocks ATP synthesis, leading cell death. Through years, mutations complex, causing resistance atovaquone, have emerged. present investigation applies molecular dynamics (MD) simulations study how ...

had a few convulsions but no impaired consciousness or other signs of severe malaria. On day 2 the parasitaemia was 4%. Treatment was changed to mefloquine, which was successful. His 4 year old brother, case 2, was febrile with 0.5% infected erythro-cytes. His symptoms resolved with atovaquone and proguanil hydrochloride, and the parasites were cleared after three days. On day 28 he was again f...

Background and Aim: New anticancer drugs are being developed to avoid the toxicity chemoresistance of currently available drugs. The Food Drug Administration-approved anti-malarial drug atovaquone is known act as a selective oxidative phosphorylation inhibitor in mitochondria by competing with CO Q10 (mitochondrial complex II III). This study aimed investigate effect examining Na+/K+-ATPase (NK...

Abstract Neospora caninum is an apicomplexan parasite that causes abortion in cattle, resulting significant economic losses. There no commercial treatment for neosporosis, and drug repositioning a fast strategy to test possible candidates against N. caninum. In this article, we describe the effects of atovaquone, chloroquine, quinine, primaquine tetracycline on proliferation. The IC50 concentra...

Malaria is still considered as the major parasitic disease and development of artemisinin resistance does not improve this alarming situation. Based on recent identification relevant malaria targets in context, novel drug combinations were evaluated against artemisinin-sensitive artemisinin-resistant Plasmodium falciparum parasites. Corresponding hybrid molecules also synthesized for comparison...

Terbinafine is a synthetic antifungal agent which has recently been found to be highly effective against Pneumocystis carinii. This study evaluated the efficacy of terbinafine on rat P. carinii antigenic profile and the immune response by Western blot analysis, in comparison with atovaquone and co-trimoxazole in rats with pneumocystosis. Terbinafine was shown to target two specific major antige...

We present a case of a 52-year-old woman of Ghanaian origin who developed Plasmodium falciparum malaria 4 years after leaving Africa. She had not returned to an endemic area since. We hypothesize several possible scenarios to explain this infection, of which we believe recrudescence of P. falciparum is the most plausible. This occurred most likely as a consequence of waning immunity several yea...

BACKGROUND Approximately one-third of dogs confiscated during dogfighting investigations are infected with Babesia gibsoni. Traditional management of B. gibsoni with polymerase chain reaction (PCR)-screening, treatment with commercially available azithromycin and atovaquone, and PCR testing after 60 and 90 days is costly and impractical for large numbers of dogs at a time. HYPOTHESIS/OBJECTIV...

Long-term travelers to areas where malaria is endemic are at risk for this potentially fatal disease; however, malaria can be prevented through the use of insecticide-treated bednets, mosquito repellents, and chemoprophylaxis. Three options for chemoprophylaxis are available in the Africa region: mefloquine, doxycycline, and atovaquone-proguanil. These options differ by dosing regimen, cost, an...