Poly(ADP-ribosyl)ation is a posttranslational protein modification, which is catalyzed by poly(ADP-ribose) polymerase-1 (PARP-1) and plays a role in DNA repair and maintenance of genomic stability. A decrease in cellular poly(ADP-ribosyl)ation has been implicated in the aging process. As PARP-1 is a zinc finger protein its decreased function might be related to age-related zinc deficiency. To t...

The paper presents a model of fiscal and monetary policy that evaluates the tradeoff be­ tween higher distortionary labor taxation and higher ination in the resolution of fiscal crises. In the model government debt is domestically held and nominal. Data are presented to show that such debt is now at least as important as external government debt in many key emerg­ ing markets, and that it is a...

in thermal cracking plants, it is desired to apply an optimal temperature profile along the reactor to minimize the operation cost. in this article a simulator is developed by the use of a mathematical model, which describes the static operation of a naphtha thermal cracking pilot plant. the model is used to predict the steady state profiles of the gas temperature and product yields. using a dy...

Chromatin-modifying factors play key roles in transcription, DNA replication and DNA repair. Post-translational modification of these proteins is largely responsible for regulating their activity. The FACT (facilitates chromatin transcription) complex, a heterodimer of hSpt16 and SSRP1, is a chromatin structure modulator whose involvement in transcription and DNA replication has been reported. ...

AgentSpeak is a rea tive planning language for programming autonomous agents. It has re ently been shown that model he king te hniques an be applied to the veri ation of AgentSpeak systems, through a translation to promela, the model spe i ation language for the SPIN LTL modelhe king system. In this paper, we introdu e an alternative veri ation approa h for AgentSpeak, by translating AgentSpeak...

Analytical simulation of the in ation process of in atable structures is key to assessing their robust deployment in a space environment. Although the problem seems to be intractable, a simpliŽ ed Ž nite volume in ation model is developed, which allows discretized description of the gas  ow, pressure variation, and resulting nonlinear large deformation throughout domains of the in atable s...

Sticky-price models often suggest that relative price distortion is a major cost of in‡ation. We provide an intuition for this: Even at low rates, in‡ation strongly a¤ects price dispersion which in turn has an impact on the economy qualitatively similar to, and of the order of magnitude of, a negative shift in productivity. The utility cost of price dispersion is quanti…ed and its impact on opt...

s paper emphasizes the importance of aneously performing joint spatial and tonal ation when dealing with differently exposed s. This is supported by analyzing an example only jointly simultaneous registration provides rrect result. The registration approach utilizes an ive function that minimizes the sum of the tive variance over pixels of a global coordinate This allows for the pair-wise or si...

The pinna, or ex ternal ear, has been shown experim entally to perform an acoustical tran sfo r­ m ation essential to localization in hum an hearing. The m athem atical form of th e tran sfo rm a­ tion is given, the inverse to the transform ation is shown to exist, and a theory of localization constructed from the evidence. The theory is extended to reverberation and o ther facets of hum an hea...