OBJECTIVE To evaluate the prevalence of antinuclear antibodies (ANA) in patients with autoimmune thyroid diseases (ATD) and the presence of systemic autoimmune disorders among ANA positive patients with ATD. METHODS 168 consecutive patients with ATD with positive antithyroid antibodies and 75 healthy subjects were tested for the presence of ANA. ANA positive patients were further evaluated by...

The AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) subfamily of iGluRs (ionotropic glutamate receptors) is essential for fast excitatory neurotransmission in the central nervous system. The malfunction of AMPARs (AMPA receptors) has been implicated in many neurological diseases, including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. The active channel...

Intact adult male rats, in which aromatization of testosterone to estradiol was prevented pre- and/or neonatally by ATD (1,4,6-androstatriene-3,17-dione), were repeatedly tested for partner preference behavior (choice: estrous female vs active male). In consecutive tests increasing preference scores for the female were found. Neonatal ATD males showed significantly lower preference scores for a...

INTRODUCTION Hyperthyroidism in pregnant women should be adequately treated to prevent maternal and fetal complications, but teratogenic effects of antithyroid drug (ATD) treatment have been described. Evidence is still lacking in regard to the safety and choice of ATD in early pregnancy. OBJECTIVE Our objective was to determine to which degree the use of methimazole (MMI)/carbimazole (CMZ) a...

This study was conducted to evaluate the performance of black gram (Vigna mungo.L) grown under drought stress using coir waste manure and cow dung manure. Two varieties of black gram-ATD mash 3 and ATD mash 1 were the treatment variables. A best fit positive relationship existed between leaf chlorophyll and leaf nitrogen content with two organic manures. N, P and K accumulation in the two varie...

74 type II diabetes mellitus patients (37 males and 37 females), were compared with 74 controls, nondiabetics. Significant dermatoglyphic changes were noted between diabetics and nondiabetics. Whorls were the predominant digital pattern noted in both hands of male as well as female diabetics. This was seconded by presence of ulnar loops. There was no significant difference in the atd angle betw...

The Hybrid III 6-year-old ATD has been benchmarked against adult-scaled component level tests but the lack of biomechanical data hinders the effectiveness of the procedures used to scale the adult data to the child. Whole body kinematic validation of the pediatric ATD through limited comparison to post mortem human subjects (PMHS) of similar age and size has revealed key differences attributed ...

OBJECTIVES Autoimmune thyroid diseases (ATDs) frequently accompany myasthenia gravis (MG) and may influence its course. We aimed to determine the association and impact of ATD with early- (<50 years), late-onset MG, or thymoma-MG. MATERIALS AND METHODS Prevalence of ATD was measured in a cross-sectional study of 343 consecutive patients with MG (236 F, 107 M) aged 4-89 years; 83.8% were serop...

Neurochemical mechanisms mediating the interaction between emotional and cognitive processing are not yet fully understood. Here, we utilized acute tryptophan depletion (ATD) to reduce the brain synthesis of serotonin (5-HT), which is thought to have a central role in regulation of emotions and mood in humans. ATD effects on event-related potentials and magnetic fields were studied using a pass...

Serotonin (5-hydroxytryptamine, 5-HT) is known to play a role in a wide variety of functions including: mood, anxiety, sleep, aggression, sexual function and cognitive function. In the past decade, the sudden interest in acute amino acid depletion paradigms has stimulated the interest in studying the function of 5-HT in man in vivo. In particular, investigating the association of experimentally...