1. Arterial plasma histamine concentrations, forced expiratory volume in 1.0 s (FEV1.0) and peak expiratory flow rate were determined in nine patients with exercise-induced asthma and in five control subjects before and after 8 min of cycle-ergometer exercise. 2. In the controls neither FEV1.0 nor peak expiratory flow rate fell by more than 5% in any individual during the 30 min postexercise pe...

asthma is a common respiratory disorder which often exacerbated during sleep. this study was done to determine sleep disorders among patients suffered from asthma. in this cross-sectional descriptive study, 95 asthmatic patients were selected using convenient sampling method. a questionnaire consisting of both demographic information and global sleep assessment was employed to gather data. resu...

Background Bronchial smooth muscle (BSM) remodelling in asthma is related to an increased mitochondrial biogenesis and enhanced BSM cell proliferation asthma. Since mitochondria produce the highest levels of cellular energy fatty acid β-oxidation most powerful way ATP, we hypothesised that, asthmatic cells, energetic metabolism shifted towards acids. Objectives We aimed characterise both vitro ...

Asthma and eosinophilia are two closely related pathologies whose interaction is key in the era of precision medicine. However, this relationship rarely taken into account without influence therapeutic prescriptions. In study involving 1296 subjects, between asthma was analyzed taking other biases. We observed that rhinitis only appears non-asthmatic patients with elevated blood eosinophil leve...

assesment of health related quality of life (hrql) is increasingly recognized as an important part of the patient care in asthma. we aimed to evaluate the effect of personality disorders (pds) on hrql and the severity of disease in asthmatic patients. ninety seven consecutive patients with asthma and ninety healthy controls were included. all  patients  completed  a  short  form-36  health  sur...

Thirty-two patients with clinical diagnosis of bronchial asthma were evaluated. Serum IgE levels, measured by the Phadebas IgE test, were clearly increased in the patients with asthmatic attack compared with those without asthmatic attack. When the patients were grouped according to the clinical grading of severity of asthmatic attack, the levels showed the significant elevation in proportion t...

Appreciable numbers of aspirin-sensitive asthmatic patients have chronic steroid-dependent severe asthmatic symptoms. We report four cases of aspirin-sensitive asthmatics who had mild to severe asthmatic symptoms, whose methacholine PC20 level ranged from 0.6 to 22 mg/ml at the first visit. The aspirin sensitivity was confirmed by lysine-aspirin bronchoprovocation. After anti-asthmatic medicati...

Objective(s) Deregulation of the immune system through allied factors and cytokine responses are thought to be important contributors to the pathogenesis of asthma. Vitamin D3 and its nuclear receptor appear to be factors that maybe involved in regulating immune responses during the progression of asthma. The aim of this study was to investigate the association between polymorphisms in intron ...

Measurement of the total resistance of the respiratory system (Rrs) is an attractive alternative to measurement of forced expiratory volume in one second (FEV1) in young children because it requires minimal co-operation. The purpose of this study was to assess the ability of the forced oscillation technique (FOT) to detect airway obstruction in asthmatic children and in patients with cystic fib...