Among the many factors that affect ventilatory function in the asthmatic subject, physical exercise and bronchodilator drugs are two of the more important. It has been shown that physical exercise has two distinct and opposite effects on ventilatory function depending upon the duration and level of exercise (Jones, Buston and Wharton, 1962). Providing the level is adequate, exercise lasting les...

OBJECTIVE To review basic concepts, inhalation therapy, classification of asthma and peculiarities of asthma in developing countries. SOURCES Direct search in the Medline, HighWire and MD Consult databases. SUMMARY OF THE FINDINGS Inhaled corticosteroids are the drugs of choice for the treatment of asthma. Alternatively, other drugs, such as long-acting beta-agonists and antileukotrienes co...

Background: Asthma is one of the most common chronic illness worldwide. For prevention exacerbations, patients bronchial asthma are kept on long-term treatment that why they amenable for adverse drug reactions (ADRs). The study was planned to monitor ADRs with intervention anti-asthmatic drugs in adults visited medicine outpatient or admitted inpatient department a tertiary care teaching hospit...

PURPOSE In the USA and Europe, hypovitaminosis D is associated with increased asthma severity, emergency department (ED) visit, and impaired pulmonary function in asthmatic patients. However, in tropical countries, data on the effect of vitamin D status on asthma is limited. This study evaluates the relationship between vitamin D status and the level of asthma control as well as other asthmatic...

Many potential new asthma therapies that show promise in the pre-clinical stage of drug development do not demonstrate efficacy during clinical trials. One factor contributing to this problem is the lack of human-relevant models of the airway that recapitulate the tissue-level structural and functional phenotypes of asthma. Hence, we sought to build a model of a human airway musculature on a ch...

An H1-receptor blocking antihistamine, clemastine, taken before aspirin gave complete or partial protection against flushing, rhinorrhea, cough, and headache in ten asthmatic patients with idiosyncrasy to aspirin. In five of the ten patients aspirin-precipitated bronchoconstriction was also reduced or prevented after pretreatment with clemastine. Thus histamine appears to play a part in the pro...

The aim of this study was to evaluate the impact of a written asthma action plan (WAAP) on reducing unscheduled doctor visits, asthma control and quality of life in children with all severities of asthma. This was a randomised controlled, single-blinded study whereby 80 children with asthma were randomly assigned to be either provided a WAAP or verbally counseled . The number of asthmatic exace...

BACKGROUND The prevalence of asthma appears to be on the increase and the risk factors are not well established. Environmental and demographic characteristics of asthmatic children were investigated to identify the risk factors accompanying asthma. METHODS 140 asthmatic children aged at 3-15 years were compared with 96 age-matched control subjects admitted to the paediatric outpatient clinics...