Currently, a substantial proportion of Antarctic research is carried out through deployment of field camps, but little detailed information on the running of these facilities is often available. The remoteness of camps and the fragility of local Antarctic terrestrial ecosystems make the running of sustainable, low impact field science and logistics in ice-free areas a challenge for environmenta...

A novel and efficient one-pot three-enzyme cascade method for the synthesis of β-alanine from maleic acid was developed. Two recombinant E. coli strains were constructed. The (MaiA-AspA) co-expressing cis-trans isomerase (MaiA) L-aspartase (AspA) catalyzed biotransformation to L-aspartate via fumaric acid, (ADC) expressing L-aspartate-α-decarboxylase bioconversion β-alanine. After systematic op...

As a part of the Next Generation Air Transportation System (NextGen), the Federal Aviation Administration (FAA) is developing an advanced airborne Merging and Spacing (M&S) concept utilizing satellite-based surveillance information provided by Automatic Dependent SurveillanceBroadcast (ADS-B). The M&S concept is defined as Airborne SpacingFlight deck Interval Management (ASPA-FIM), which includ...

Canavan disease (CD) (OMIM 271900) is an autosomal recessive leucodystrophy characterised by swelling and spongy degeneration of the white matter of the brain. The biochemical marker for the disorder is increased level of N-acetylaspartic acid (NAA) in cerebrospinal fluid and urine owing to aspartoacylase (ASPA) deficiency. 2 The disease is caused by mutations in the gene encoding the enzyme as...

Canavan disease is caused by mutations in the gene encoding aspartoacylase (ASPA), a deacetylase that catabolizes N-acetylaspartate (NAA). The precise involvement of elevated NAA in the pathogenesis of Canavan disease is an ongoing debate. In the present study, we tested the effects of elevated NAA in the brain during postnatal development. Mice were administered high doses of the hydrophobic m...

The nucleotide sequence of a 3,162-base-pair (bp) segment of DNA containing the FNR-regulated fumB gene, which encodes the anaerobic class I fumarase (FUMB) of Escherichia coli, was determined. The structural gene was found to comprise 1,641 bp, 547 codons (excluding the initiation and termination codons), and the gene product had a predicted Mr of 59,956. The amino acid sequence of FUMB contai...

R Menéndez, A Torres, R Zalacaı́n, J Aspa, J J Martı́n Villasclaras, L Borderı́as, J M Benı́tez Moya, J Ruiz-Manzano, F Rodrı́guez de Castro, J Blanquer, D Pérez, C Puzo, F Sánchez Gascón, J Gallardo, C Álvarez, L Molinos (Neumofail Group) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

Abstract The southern elephant seal (SES; Mirounga leonina ) has a circumpolar distribution, breeding mainly on sub‐Antarctic islands and making long trips between or molting foraging areas. Most individuals from colonies in the South Shetland Islands (western Antarctic Peninsula; WAP) are distributed Specially Protected Areas (ASPA). Despite these protected habitats, pollutants can reach such ...