OBJECTIVE To investigate the status of the oxidant/antioxidant balance in patients with multiple myeloma compared to healthy controls. MATERIALS AND METHODS This study was conducted on 40 multiple myeloma patients and 40 healthy controls of matched age and sex. Serum total thiol, oxidative stress index (OSI), total oxidant status (TOS), and total antioxidant status (TAS) were measured using c...

Fats and oils as major dietary components are involved in the development of chronic diseases. In this paper the physiological relevance and some methodological aspects related to the determination of two enzymes enrolled in metabolism of fat – pancreatic lipase and arylesterase – are discussed. Pancreatic lipase has been extensively used to study the triacylglycerol fatty acid composition and ...

INTRODUCTION In this study we aimed to detect paraoxonase 1 (PON-1) activity in iron deficiency anemia (IDA) and to compare it with healthy controls by observing the change after iron therapy. MATERIAL AND METHODS In this study, 50 adult patients with IDA and 40 healthy subjects were enrolled. All patients were analyzed at the beginning and after treatment according to laboratory assessments....

BACKGROUND It has been suggested that physical activity is an important factor in the prevention and treatment of cardiovascular diseases. Low serum paraoxononase-1 (PON1) activity is with an associated risk of atherosclerotic disease. OBJECTIVES In this study, we aimed to investigate serum PON1 activity and lipid hydroperoxide (LOOH) levels in adult football players after three days football...

background: paraoxonase-1(pon1), a high-density lipoprotein (hdl) associated enzyme, is believed to contribute in the patho­genesis of coronary artery disease (cad). the aim of this study was to evaluate the association of pon1 promoter c (-107)t polymorphism with the extent of coronary artery stenosis in iranian patients. methods : the rflp analysis for determination of the c(-107)t genotype d...

background: arsenic as an environmental toxicant is able to induced oxidative stress. the present study aimed to evaluate of vitamin c supplementation on the paraoxonase1 (pon1) arylesterase activity (responsible for hydrolysing lipid-peroxides) in rat exposed to arsenic. methods: the study was conducted in the faculty of veterinary medicine, tabriz islamic azad university, tabriz, iran in 2001...

Membrane proteins play key roles in fundamental biological processes, such as transport of molecules, signalling, energy utilization, and maintenance of cell and tissue structures. Serum paraoxonase (PON1, EC 3.1.8.1.) is a protein of 354 amino acids with a molecular mass of 43 kDa is a high density lipid (HDL) associated, calcium-dependent enzyme whose 3D structure, active site residues and ph...