Introduction: Although, the effect of direct intra-articular injection of bone marrow stem cells (BMSCs) on the repair of articular cartilage and the effect of Elaeagnus angustifolia extract on pain relief in patients with osteoarthritis have been investigated, no studies has been conducted to compare the effects of these two therapeutic methods on the mechanical properties of articular cartila...

Degenerative joint disease is a major cause of functional disability and pain affecting globally hundreds of millions people. In the western countries, osteoarthritis is a major joint disease most often affecting people over 65 years of age. Aging, joint loading, articular cartilage injuries, obesity, and genetic factors are known to influence the development of osteoarthritis. In osteoarthriti...

BACKGROUND Articular cartilage injury remains a major challenge in orthopedic surgery. This study aimed to identify differences in gene expression and molecular responses between neonatal and adult articular cartilage during the healing of an injury. METHODS An established in vitro model was used to compare the transcriptional response to cartilage injury in neonatal and adult sheep by microa...

OBJECTIVE Human osteoarthritis (OA) is characterized by a pathologic shift in articular cartilage homeostasis toward the progressive loss of extracellular matrix (ECM). The purpose of this study was to investigate the ability of rAAV-mediated SOX9 overexpression to restore major ECM components in human OA articular cartilage. METHODS We monitored the synthesis and content of proteoglycans and...

Osteoarthritis has as main characteristics the degradation of articular cartilage and the formation of new bone at the joint edges, so-called osteophytes. In this study enhanced expression of TGF-beta1 and -beta3 was detected in developing osteophytes and articular cartilage during murine experimental osteoarthritis. To determine the role of endogenous TGF-beta on osteophyte formation and artic...

OBJECTIVE To examine articular cartilage from a number of joint sites, using a large sample group, for the presence of magnesium whitlockite crystal deposition. METHODS Articular cartilage specimens were taken from a total of 70 patients. The majority of specimens were taken from femoral heads, with smaller numbers from femoral condyle, tibial plateau, radius, ulna, and several small peripher...

BACKGROUND The full-thickness articular cartilage defects of knee have a poor healing capacity that may progress to osteoarthritis and need a knee replacement. This study determines the healing effect of bioglue in fullthickness articular cartilage defect of femoral condyle in rabbit. METHODS Forty-eight male rabbits were randomly divided into four equal groups. In group A, 4 mm articular car...

OBJECTIVE Previous work has shown that increasing the production of boundary lubricant, superficial zone protein (SZP), did not reduce the friction coefficient of self-assembled articular cartilage constructs and was possibly due to poor retention of the lubricant. The aim of this investigation was to reduce the friction coefficient of self-assembled articular cartilage constructs through enhan...

Injuries to the articular cartilage and meniscal tissue often result in pain and dysfunction, which can interfere with normal activities of daily living and limit athletic participation. Articular cartilage is hylaline cartilage and its poor inherent ability to heal has been cited in the literature as far back as 1743. Long-term damage to either the articular cartilage and to the menisci may pr...

Mild discolouration of the articular cartilage is known to gradually occur during aging. However, pathological tissue pigmentation is occasionally induced under several specific conditions. In the present case, we performed total knee replacement in a patient with recurrent haemarthrosis. However, during the operation, we observed severe black colouration of the knee articular cartilage, due to...