Autonomously replicating sequence (ARS) elements, which function as the cis-acting chromosomal replicators in the yeast Saccharomyces cerevisiae, depend upon an essential copy of the 11-bp ARS consensus sequence (ACS) for activity. Analysis of the chromosome III replicator ARS309 unexpectedly revealed that its essential ACS differs from the canonical ACS at two positions. One of the changes obs...

OBJECTIVE Lithium remains the most widely used treatment for bipolar disorder; however, the molecular mechanisms underlying its therapeutic actions have not been fully elucidated. We studied the in-vivo effect of lithium on the density of alpha-adrenoceptor (alpha-AR) and beta-AR subtypes and linked second messenger systems in the rat brain. METHODS The densities of alpha(1)-ARs, alpha(2)-ARs...

OBJECTIVE Vascular abnormality includes two forms, arteriosclerosis (ARS) and atherosclerosis (ATS), which coexist in patients with cardiovascular (CV) diseases. However, whether their combination may lead to a worsening status in those patients remains unclear. We therefore aimed to investigate the association of ARS and/or ATS with hypertensive target organ damage (TOD). METHODS From June 2...

OBJECTIVE The purpose of this study is to examine the validity of primary screening tools for attention deficit hyperactivity disorder (ADHD) in a community-based sample of children using the Korean version of the Child Behavior Checklist (K-CBCL) and the Korean version of the ADHD Rating Scale (K-ARS). METHODS A large-scale community-based study for ADHD screening was conducted in the Jeolla...

Dihydroartemisinin (DHA) and artesunate (ARS), two artemisinin derivatives, have efficacious anticancer activities against human hepatocarcinoma (HCC) cells. This study aims to study the anticancer action of the combination treatment of DHA/ARS and farnesylthiosalicylic acid (FTS), a Ras inhibitor, in HCC cells (Huh-7 and HepG2 cell lines). FTS pretreatment significantly enhanced DHA/ARS-induce...

©2018 Turkish League Against Rheumatism. All rights reserved. ABSTRACT Objectives: This study aims to analyze the distribution and clinicopathological characteristics of anti-aminoacyl-transfer ribonucleic acid (tRNA) synthetase (ARS) antibodies in rheumatoid arthritis patients. Patients and methods: We retrospectively studied the anti-ARS antibody levels in 228 RA patients’ (44 males, 184 fema...

LEVERAGE AND LIQUIDITY: EVIDENCE FROM THE CLOSED-END FUND INDUSTRY BY YUEHUA TANG APRIL 19, 2013 Committee Chair: VIKAS AGARWAL Major Academic Unit: YUEHUA TANG This paper uses the February 2008 auction rate security (ARS) market freeze to examine the spillover effects of an exogenous funding liquidity shock on the underlying asset markets. Consistent with theory, I find that the stocks held by...

Earlier studies on the H4 autonomously replicating sequence (ARS) identified a DNA unwinding element (DUE), a required sequence that is hypersensitive to single-strand-specific nucleases and serves to facilitate origin unwinding. Here we demonstrate that a DUE can be identified in the C2G1 ARS, a chromosomal replication origin, by using a computer program that calculates DNA helical stability f...

The correlation of symptoms (SX) with major arrhythmias (ARS) occurring during 24-hour ambulatory monitoring (AM) was investigated in a goup of patients referred because of dizziness or syncope. Ninety-eight consecutive patients, ages 25 to 82, who had adequate diaries of activities and SX, wre included. The ARS considered to be major were ventricular and supraventricular ectopy grade 2, 3, and...

SUMMARY Asymmetric cell division in unicellular organisms enables sequestration of senescence factors to specific subpopulations. Accumulation of autonomously replicating sequence (ARS) plasmids, which frequently emerge from recombination within the highly repetitive ribosomal DNA locus, is linked to limited replicative life span of Saccharomyces cerevisiae cells [1]. During budding yeast cell ...