Concentrations of organic acids in prebiotic soils were presumably low, given limitations in abiotic synthesis and the limited lifetimes of organic molecules before the ultraviolet shield developed on early Earth. Prokaryotes, the first landcolonizing organisms, commonly secrete aliphatic carboxylic acids, and, less extensively, secrete aromatic compounds as siderophores and antibiotics. In con...

The support vector machines (SVM), as a novel type of learning machine, were used to develop a quantitative structure-mobility relationship (QSMR) model of 58 aliphatic and aromatic carboxylic acids based on molecular descriptors calculated from the structure alone. Multiple linear regression (MLR) and radial basis function neural networks (RBFNNs) were also utilized to construct the linear and...

An effective protocol has been developed that allows the smooth protodecarboxylation of diversely functionalized aromatic carboxylic acids within 5-15 min. In the presence of at most 5 mol % of an inexpensive catalyst generated in situ from copper(I) oxide and 1,10-phenanthroline, even nonactivated benzoates were converted in high yields and with great preparative ease.

This work describes two new synthetic methods for the efficient preparation of isoflavones following Ni-catalysed domino arylation reactions vast range ortho-hydroxyarylenaminones utilising aromatic bromides as well carboxylic acids. The presented protocols tolerated significant variation all coupling partners and enabled synthesis isoflavone library twenty-three representatives. is first commun...

The ability of the isolated Ringer-perfused frog liver, to concentrate dyestuffs in its secretion several hundred times, can be abolished entirely and reversibly by replacing in the Ringer solution about 1/8 of the NaCl by the isosmotic amount of a surface-inactive non-electrolyte (disaccharide, hexose, pentose, polyhydric alcohol, amino acid, acid amide) or electrolyte (salts of lower fatty ac...

Acyl CoA derivatives of a number of cinnamic and benzoic acids have been synthesised via the appropriate acyl phenyl thiol esters. The reaction has potential application in the preparation of acyl CoA derivatives of radiolabelled aromatic carboxylic acids. UV absorption spectra have been determined for the CoA thiol esters following their purification by gel permeation chromato­ graphy. By comp...