The performance of Kernel Machines depends to a large extent on its kernel function and hyperparameters. Selecting these is traditionally done using intuition or a costly “trial-and-error” approach, which typically prevents these methods from being used to their fullest extent. Therefore, two automated approaches are presented for the selection of a suitable kernel function and optimal hyperpar...

Background: Although alterations in resting-state functional connectivity between brain regions have previously been reported in Parkinson’s disease (PD), the spatial organization of these changes remains largely unknown. Here, we longitudinally studied brain network topology in PD in relation to clinical measures of disease progression, using magnetoencephalography and concepts from graph theo...

Objective: To assess the ability of neurophysiological markers in conjunction with cognitive assessment to improve prediction of progression to dementia in Parkinson’s disease (PD). Methods: Baseline cognitive assessments and magnetoencephalographic recordings from 63 prospectively included non-demented PD patients were analyzed in relation to PDrelated dementia (PDD) conversion over a 7-year p...

The silkworm is the larva or caterpillar of the domesticated silkmoth, Bombyx mori and being a primary producer of silk is an economically important insect. These days the silk is emerging as a resource for solving a broad range of biological problems. The silk (Abresham) is popularly known as Abresham muqriz (muqriz means cut) in Unani medicine. Its cocoons are extensively used as an ingredien...

2 Abstract Every rail operator wishes to minimise the size of their locomotive fleet in order to reduce costs. This minimum fleet size problem requires a rail operator to allocate locomotives to the trains in a predefined train schedule so that the total number of locomotives required is minimised. The key to this is deciding how and when to transfer locomotives to where they can be better util...

PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit Twente, op gezag van de rector magni…cus, prof. dr. Acknowledgements The journey to completing this PhD has not always been an easy one especially since I did it in combination with my work and family life. I would like to thank all those people who assisted and supported me in this e¤ort. Firstly, I would like to thank my...

Proefschrift ingediend met het oog op het behalen van de graad van Doctor in de Wetenschappen 2006 Guts, guts, got no guts and stitches don't help at all. Acknowledgements I would like to start by thanking my supervisor, Alexander Sevrin, for numerous reasons. First of all for his courses that opened up the broad world of quantum field theory, general relativity and ultimately string theory to ...