Over the past several decades, dental researchers reported different aspects of oral submucous Fibrosis (OSMF). Yet, there is a big lacunae in the present scenario of evidence based dentistry which correlates the role of taste perception among OSMF affected individuals and areca nut chewers. The present study intends to assess and compare different taste perception among areca nut chewing, OSMF...

BACKGROUND Snail is an important transcription factor implicated in several tumor progression and can be induced by reactive oxygen species (ROS). Areca quid chewing is a major risk factor of oral squamous cell carcinoma (OSCC). Therefore, we hypothesize that the major areca nut alkaloid arecoline may induce Snail via ROS and involve in the pathogenesis of areca quid chewing-associated OSCC. ...

The betel nut is commonly used as a drug by Asian populations. A high prevalence of adverse pregnancy outcomes has been reported in women who chewed betel quid during gestation. The hypothesis that chronic exposure of the fetus to arecoline (the principal alkaloid of the areca nut) is the cause was investigated in a clinical observational study on six newborns from Asian mothers who chewed bete...

Oral submucous fibrosis (OSMF) is a potentially malignant condition that typically affects the buccal mucosa, lips, retro molar areas and the soft palate. It presents as a whitish-yellow discoloration involving the buccal mucosa, the oropharynx and rarely in the larynx. It has a chronic, insidious biological course (Chen et al., 2006). Out of all cancer i.e. oral cancer itself it is the sixth m...

Abstract Community dependence on logging forest resources which exceeds the carrying capacity limit. The existence of natural in form Non-Timber Forest Products can directly reduce exploitation timber products. Method data collection were interview technique and field observation. results showed that types non-timber products (HHBK) have economic potential are sugar palm ( Arenga pinnata ), pat...

This study is focused on piper betel/arecanut chewing in Kalinga. It aimed to explore the Kalinga epic, Ullalim find out cultural significance of betel/areca nut chewing. The literary analysis epic revealed that there are significances and ethno-therapeutic effects betel/ areca reflected Ullalim. then recommended young chewers should become more aware social nut.

Chewing areca nut is closely associated with oral squamous cell carcinoma (OSCC). The current study aimed to investigate potential associations between areca nut extract (ANE) and cisplatin toxicity in OSCC cells. OSCC cells (Cal-27 and Scc-9) viability and apoptosis were analyzed after treatment with ANE and/or cisplatin. The expressions of proteins associated with autophagy and the AMP-activa...

The present study sought to investigate the predictive value of preoperative clinicopathological variables, with a special focus on areca nut chewing, on disease recurrence and progression in patients with non-muscle-invasive bladder cancer (NMIBC). Data from 242 patients diagnosed with NMIBC between 2008 and 2013 were analyzed retrospectively. Fifteen clinicopathological variables were analyze...

BACKGROUND Early growth response-1 (Egr-1) protein plays an important role in many human fibrotic diseases. Areca nut chewing is the most important risk factor of oral submucous fibrosis (OSF). METHODS Egr-1 protein expression in OSF was examined using antibody to Egr-1. Arecoline-induced Egr-1 expression and its signaling pathways were assessed by Western blot analyses in human buccal mucosa...

Betel quid chewing is an ancient practice common in many countries of Asia and among migrated communities in Africa, Europe and North America. It enjoys complete social acceptance in many societies and is also popular among women. In its most basic form, betel quid consists of betel leaf (Piper betel), areca nut, the main psychoactive ingredient, and slaked lime (calcium hydroxide). Areca nut i...