INTRODUCTION The syndrome of fever is a commonly presenting complaint among persons seeking healthcare in low-resource areas, yet the public health community has not approached fever in a comprehensive manner. In many areas, malaria is over-diagnosed, and patients without malaria have poor outcomes. METHODS AND FINDINGS We prospectively studied a cohort of 870 pediatric and adult febrile admi...

When an arbovirus enters an arthropod in an infected blood meal, several mechanisms may interact to affect its life cycle and ultimate transmissibility. Intrinsic absolute failure in the establishment of infection must be contrasted with infection that is successfully established but is variably modulated in its viral yield throughout the vector's life-span. Degrees of vertebrate host resistanc...

BACKGROUND Vector arthropods control arbovirus replication and spread through antiviral innate immune responses including RNA interference (RNAi) pathways. Arbovirus infections have been shown to induce the exogenous small interfering RNA (siRNA) and Piwi-interacting RNA (piRNA) pathways, but direct antiviral activity by these host responses in mosquito cells has only been demonstrated against ...

Noninfectious arbovirus antigens were prepared from borate-saline suspensions of infected suckling mouse brain buffered with tris(hydroxmethyl)aminomethane and treated with beta-propiolactone (BPL). The activity and stability of these antigens were enhanced by altering the buffering system, by passing the virus seed through a series of four or more continuous passages in the brains of suckling ...

In fact, it appears that dengue is characterized as a disease has relevance to public health in the country. For year 2019, 1,544,987 cases of could be reported, with presence 782 confirmed deaths. Regarding interruption epidemic cycles, was noted measures associated vector control have not been successful. This study aims analyze spatial distribution present municipalities state Mato Grosso, f...