accumulative roll bonding (arb) was used to fabricate the cu-zn multilayer and cu-zn solid solution. a lamellar structure with the hardness of about 130 vhn was formed after eight arb cycles. following to the suitable heat treatment, a solid solution with a uniform microstructure and hardness of about 57 vhn was produced. the dominant wear mechanism in the arb processed multilayer was found to ...

It has been shown that angiotensin I-converting enzyme inhibitors (ACEIs) and angiotensin II type-1 receptor blockers (ARBs) can decrease tumor growth and tumor-associated angiogenesis and inhibit metastasis. Epidermal growth factor receptor (EGFR) mutations are found in approximately 30% of patients with advanced non-small cell lung cancer (NSCLC) in East Asia and in 10-15% of such patients in...

The remodeling of gap junctions may affect their conduction properties and contribute to the maintenance of atrial fibrillation. The significance of the role of angiotensin-II receptor blockers (ARBs) in upstream therapy is not clear. This study was performed to investigate the effects of ARBs on atrial remodeling in a heart failure model. A model of heart failure was established or sham surger...

BACKGROUND It is controversial whether angiotensin-converting enzyme inhibitors (ACEI)/angiotensin receptor blockers (ARB) provide significant survival benefits in patients with coronary artery disease (CAD) but without myocardial infarction (MI). This study investigated whether the association of ACEI/ARB therapy with clinical outcome in patients undergoing percutaneous coronary intervention (...

This paper was prepared as the result of work sponsored by the California Air Resources Board (ARB) and the California Environmental Protection Agency (Cal/EPA). It does not necessarily represent the views of the California Energy Commission, ARB, Cal/EPA, their employees, or the State of California. The Energy Commission, ARB, Cal/EPA, the State of California, their employees, contractors, and...

Metaphase and anaphase spindles in cultured newt and PtK1 cells were irradiated with a UV microbeam (285 nM), creating areas of reduced birefringence (ARBs) in 3 s that selectively either severed a few fibers or cut across the half spindle. In either case, the birefringence at the polewards edge of the ARB rapidly faded polewards, while it remained fairly constant at the other, kinetochore edge...

Angiotensin II (A-II) receptor (AT(1) receptor) blockers (ARB) are a class of antihypertensive agent. It is known that they suppress signal transduction pathways mediated by growth factors [e.g., epidermal growth factor (EGF)] through the AT(1) receptor in vascular endothelial cells. In the present study, we demonstrated that A-II activates the cell proliferation of prostate cancer as well as E...

In this paper, an extended accumulative roll bonding (ARB) technique, called the 'Four-Layer Accumulative Roll Bonding (FL-ARB)' technique, is presented for the first time. This technique has been employed to produce ultrafine-grained commercial pure aluminum sheets with success. After three FL-ARB passes, the grain size of pure aluminum was seen to reduce to 380 nm. The bonding strength of the...

BACKGROUND Both angiotensin II type I receptor blockers (ARBs) and calcium channel blockers (CCBs) are widely used antihypertensive drugs. Many clinical studies have demonstrated and compared the organ-protection effects and adverse events of these drugs. However, few large-scale studies have focused on the effect of these drugs as monotherapy on laboratory parameters. We evaluated and compared...